Corilagin
Synopsis of Corilagin
History
Corilagin is a naturally occurring ellagitannin, predominantly found in a variety of medicinal plants such as Phyllanthus niruri, Terminalia chebula, and Geranium sibiricum. Historically, it has played a significant role in traditional medicine systems, especially in Ayurveda, Traditional Chinese Medicine (TCM), and folk remedies across Asia.
In Indian Ayurvedic practices, plants rich in corilagin have been used for centuries to address liver ailments, digestive disorders, and as general detoxifying agents. For example, extracts from Phyllanthus species have been utilized as a cornerstone in remedies for jaundice and hepatitis, with corilagin believed to contribute to hepatoprotective effects. In TCM, herbs containing corilagin are often incorporated into formulas targeting inflammation, diarrhea, and microbial infections, highlighting its broad therapeutic potential. Folk medicine traditions have also employed corilagin-rich plants to manage wounds, ulcers, and as a remedy for fever, owing to their reputed anti-inflammatory and antioxidant properties.
Corilagin is rarely used in isolation; it often acts synergistically in herbal combinations. When combined with other bioactive compounds—such as flavonoids, lignans, and saponins—it enhances the efficacy of multi-herb formulas. This synergy is particularly valued in digestive, liver-support, and immune-boosting blends, where corilagin’s diverse biological activities amplify the overall therapeutic impact. Its contributions to herbal medicine are celebrated for supporting holistic health, reducing oxidative stress, and promoting resilience against chronic diseases. The enduring presence of corilagin in traditional and modern formulations attests to its significant and positive legacy in natural healing practices.
Traditional and scientific validation
Corilagin is a polyphenolic compound classified as an ellagitannin, naturally occurring in various plants such as Phyllanthus species and Terminalia chebula. Historically, botanical sources rich in corilagin have been utilized in traditional medicine systems, particularly in Asia, for ailments including liver disorders, infections, and inflammation. This historical use has sparked scientific interest in uncovering the potential health benefits of corilagin as a bioactive ingredient in nutritional products.
Modern research highlights corilagin's promising pharmacological properties. In vitro and animal studies have demonstrated its antioxidant, anti-inflammatory, hepatoprotective, and antimicrobial activities. For instance, corilagin has been shown to scavenge free radicals and modulate oxidative stress pathways, which are important for cellular health. Some preclinical studies suggest corilagin may support liver function and provide protective effects against certain toxins.
While these laboratory findings are encouraging, clinical evidence in humans remains limited. A few preliminary studies suggest potential benefits, such as supporting immune function or mitigating metabolic imbalances, but large-scale, well-controlled human trials are still needed to confirm efficacy and safety. Importantly, corilagin is considered safe at typical dietary levels, with no major adverse effects reported in the available literature.
Overall, corilagin is a promising natural compound with a long history of traditional use and growing scientific interest. Its diverse biological activities make it a valuable ingredient in nutritional formulations, though further research is essential to fully substantiate its health benefits in humans.
Corilagin is used for these health conditions
Cancer (natural therapy for) (Scientific)
Cancer (prevention) (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Diabetes (Scientific)
Fatty Liver Disease (Scientific)
Hepatitis (Scientific)
Inflammation (Scientific)
Liver Detoxification (Scientific)
Ulcers (Scientific)
Corilagin is used to support these body systems
Hepatic System (Scientific)
Intestinal System (Scientific)
Liver (Scientific)
