Coleus forskohlii (plectranthus barbatus)
Synopsis of coleus forskohlii
Coleus forskohlii is a tropical perennial plant in the Lamiaceae (mint) family, native to India and parts of Southeast Asia. It is recognized for its vibrant purple-green foliage and, more importantly, for its bioactive compound forskolin, which is extracted from the plant’s root. Forskolin is a labdane diterpenoid known for its ability to activate the enzyme adenylate cyclase, increasing intracellular levels of cyclic AMP (cAMP)—a critical messenger in numerous physiological processes.
Because of its ability to raise cAMP levels, Coleus forskohlii has wide-ranging effects on metabolism, cardiovascular health, fat regulation, and cellular signaling. It is often used in modern herbal medicine and supplements to support:
- Fat loss and weight management (by stimulating lipolysis)
- Healthy blood pressure (by relaxing blood vessels and reducing vascular resistance)
- Respiratory health (through smooth muscle relaxation in the lungs, useful in asthma)
- Thyroid function and hormone balance
- Heart function and overall circulatory improvement
Additionally, forskolin has been studied for its potential to improve insulin sensitivity, modulate testosterone levels, and support eye pressure reduction in conditions such as glaucoma. Its effect on cAMP signaling also suggests roles in cognitive enhancement, immune modulation, and anti-inflammatory actions, although more robust human studies are needed for these uses.
Coleus supplements are typically standardized to 10–20% forskolin and are generally well tolerated at appropriate doses. However, it can interact with blood pressure medications, anticoagulants, and thyroid medications and should be used cautiously in those with low blood pressure or bleeding disorders.
Historical Use
In Ayurvedic medicine, Coleus forskohlii—known traditionally as Makandi or Pashanabhedi—has been used for centuries to support heart health, respiratory function, and urinary tract conditions. Ancient Ayurvedic texts describe it as a remedy for chest pain (angina), hypertension, intestinal spasm, and convulsions. It was also used to dissolve urinary stones, treat fevers, and improve circulatory vigor.
The plant was typically administered as a decoction of the root or prepared as a herbal powder mixed with ghee or honey. Ayurvedic practitioners used it to stimulate agni (digestive fire), balance vata and kapha, and promote overall energetic vitality.
Modern scientific interest in Coleus forskohlii began in the 1970s, when Indian researchers isolated forskolin and identified its unique action on cAMP. Since then, forskolin has been the subject of extensive research, particularly in the fields of metabolism, cardiovascular health, and obesity management. Its popularity surged in the West with its inclusion in weight loss supplements and metabolic enhancers, though its traditional uses extend well beyond fat metabolism.
Today, Coleus forskohlii remains an important plant in integrative medicine, bridging traditional Ayurvedic wisdom with modern biochemical insight into cAMP-related pathways.
Coleus forskohlii is used for these health conditions
Body Building (Scientific)
Circulation (poor) (Traditional)
Fat Metabolism (poor) (Scientific)
Hypertension (Traditional)
Triglycerides (high) (Scientific)
Weight Loss (Scientific)
coleus forskohlii is used to support these body systems
Bronchials (Traditional)
Circulatory System (Scientific)
Heart (Scientific)
Respiratory System (Traditional)
