Bonito peptide (katsuwonus pelamis)
Synopsis of bonito peptide
Bonito peptide refers to bioactive protein fragments derived from the enzymatic hydrolysis of bonito fish (Katsuwonus pelamis), a type of tuna commonly found in Japanese and Southeast Asian waters. These peptides are typically extracted from bonito muscle or fish flakes and have gained popularity for their cardiovascular and metabolic benefits, particularly in supporting healthy blood pressure and circulation.
Bonito peptides are rich in small amino acid sequences that exhibit ACE-inhibitory activity (angiotensin-converting enzyme inhibition), which helps:
- Lower and regulate blood pressure
- Improve vascular flexibility and endothelial function
- Reduce inflammation and oxidative stress in blood vessels
- Support heart health and circulation
- Assist in metabolic regulation and possibly fatigue reduction
They are often included in nutraceuticals, functional beverages, and blood pressure support formulas, sometimes under branded ingredient names like Bonito Peptide S, PeptACE, or similar. Bonito peptides are typically taken in capsule or tablet form, with doses standardized to their ACE-inhibitory potency.
Historical Use:
While the isolation and identification of bonito peptides are modern developments rooted in Japanese peptide research, their source—bonito fish—has been used in traditional Japanese and Southeast Asian cuisine for centuries, most famously as katsuobushi (dried, fermented, and smoked bonito flakes) used in dashi broth.
In Japanese folk tradition, foods like dashi were considered revitalizing tonics, especially for the elderly, weak, or fatigued. Though not used as a "peptide supplement," the regular consumption of bonito-based broths may have delivered similar amino acid–rich compounds, subtly supporting vascular health and energy.
Modern extraction techniques now allow for concentrated, bioavailable peptides with predictable activity, making bonito peptide a scientifically validated and natural approach to managing mild hypertension, often used as a non-pharmaceutical alternative or adjunct in integrative cardiovascular care.
Today, bonito peptides are popular in Japan, South Korea, and increasingly in Western natural health markets, offering safe, food-based support for healthy blood pressure and heart function without the side effects associated with pharmaceutical ACE inhibitors.
Bonito peptide is used for these health conditions
Cardiovascular Disease (Scientific)
Cholesterol (high) (Scientific)
Diabetes (Scientific)
Fatigue (Scientific)
Hypertension (Scientific)
Inflammation (Scientific)
Stress (Scientific)
bonito peptide is used to support these body systems
Arteries (Scientific)
Blood (Scientific)
Circulatory System (Scientific)
Heart (Scientific)
