Other names for 2-Hydroxypropyl-Beta-Cyclodextrin

citric acid hpbcd

Synopsis of 2-Hydroxypropyl-Beta-Cyclodextrin

History

2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) is a modified form of beta-cyclodextrin, a naturally occurring cyclic oligosaccharide derived from starch. Cyclodextrins have a rich history in the realm of medicinal and nutritional applications, dating back to the mid-20th century, when their unique molecular structure was first harnessed to enhance the solubility and stability of various compounds. HPβCD, in particular, was developed to overcome some limitations of the native molecule, such as poor solubility and potential toxicity at higher doses.

Historically, cyclodextrins have served as invaluable excipients in pharmaceuticals, where they have been utilized to improve the delivery and bioavailability of poorly soluble drugs and natural remedies. Their ability to form inclusion complexes with lipophilic molecules enabled the encapsulation of volatile or easily degraded herbal components, thereby preserving their potency and extending shelf life. HPβCD's superior safety profile and solubility have made it a favored choice in both pharmaceutical and nutraceutical formulations.

In the context of herbal combinations, HPβCD plays a transformative role. It allows for the effective blending of water-insoluble herbal extracts, making them more accessible and bioavailable to the body. This has led to more effective and consistent herbal remedies, ranging from traditional botanicals like curcumin to modern adaptogens. HPβCD's contribution is especially significant in enabling synergistic effects in multi-herb formulas, ensuring that active constituents are delivered efficiently and in stable forms. Overall, 2-Hydroxypropyl-Beta-Cyclodextrin stands as a testament to the power of innovation in advancing the efficacy, safety, and versatility of both conventional and herbal medicinal products.

Traditional and scientific validation

2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) is a chemically modified derivative of beta-cyclodextrin, widely recognized for its application in pharmaceuticals and nutritional products. Historically, cyclodextrins have been studied since the early 20th century for their unique ability to form inclusion complexes with various molecules, enhancing the solubility and stability of otherwise poorly soluble compounds. The hydroxypropyl modification, introduced in the late 1970s, greatly improved the aqueous solubility and safety profile of the molecule, paving the way for its broader use in food and supplement industries.

Scientifically, HPβCD has been validated for its role as a carrier molecule, improving the bioavailability of certain vitamins, minerals, and other bioactive substances in nutritional formulations. Preclinical and clinical studies have demonstrated its capacity to increase the dissolution rate and absorption of guest molecules, which can potentially lead to better health outcomes for consumers. For instance, research has shown that HPβCD can enhance the stability and palatability of fat-soluble vitamins, making them more accessible in dietary products.

While HPβCD is generally recognized as safe (GRAS) and well-tolerated at recommended dosages, comprehensive long-term studies in nutritional contexts are still limited. Current evidence supports its positive contribution to nutritional science, particularly in the enhancement of nutrient delivery. Nevertheless, ongoing research is needed to fully elucidate its benefits and any potential effects in diverse populations. Overall, HPβCD represents a promising and innovative ingredient that continues to support advancements in nutritional product development.

2-Hydroxypropyl-Beta-Cyclodextrin is used for these health conditions

Alzheimer's Disease (Scientific)

This ingredient is used to support these body systems

None

Products containing 2-Hydroxypropyl-Beta-Cyclodextrin

We currently have no products on Caring Sunshine that contain this ingredient.