Evidence supporting the use of: Vitamin A
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A is scientifically recognized for its role in skin health and aging prevention, especially in the form of topical retinoids (like retinol and tretinoin). Retinoids are derivatives of vitamin A and are widely used in dermatology to treat photoaging, fine lines, wrinkles, and hyperpigmentation. Numerous randomized controlled trials and meta-analyses have demonstrated that topical retinoids can stimulate collagen production, accelerate cell turnover, and improve overall skin texture and tone. For example, tretinoin (all-trans retinoic acid) is FDA-approved for reducing fine wrinkles, mottled hyperpigmentation, and roughness of facial skin due to chronic sun exposure. These effects are believed to be mediated through increased collagen synthesis and decreased matrix metalloproteinase activity, which helps maintain the structural integrity of the skin.

Oral vitamin A supplementation, on the other hand, is not commonly recommended for aging prevention in healthy individuals, as excessive intake can be toxic and lead to adverse effects. Most scientific support for vitamin A in aging prevention pertains to its topical use rather than oral supplementation. Historically, vitamin A–rich foods have been associated with good skin health, but modern anti-aging regimens focus on topical applications for direct efficacy.

In summary, there is solid scientific evidence (rating: 3) supporting the use of topical vitamin A derivatives for the prevention and treatment of aging-related skin changes, though oral supplementation is not generally advised for this purpose.

More about vitamin A
More about Aging (prevention)

Other ingredients used for Aging (prevention)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
7-hydroxymatairesinol (HMR)
7-Keto-DHEA
8-Prenylnaringenin
Abalone
Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
Algae
algal oil
Algal protein
Allantoin
Almond fruit
Alpha hydroxy acids
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anemarrhena asphodeloides
anserine
anthocyanidins
anthocyanins
anthocyanosides
antler
Antrodia camphorata
apigenin
apple
apricot
argan nut oil
Aronia melanocarpa
ascorbyl palmitate
ashitaba
ashwagandha
astaxanthin
astragaloside
astragalus
avocado
beta-carotene
bioflavonoids
bird\'s nest
Brassica
Brussel sprouts
Carnosine
carotene (unspecified)
carrot
catalase
cauliflower
Chinese Ligustrum berry
cistanche
coenzyme Q10 (CoQ10)
collagen
cruciferous
cryptoxanthin
curcumin
Curcuminoid
cycloastragenol
DHEA
DHEA (dehydroepiandrosterone)
dismutase
dodder
Dunaliella
Dunaliella salina
ellagic acid
epicatechin
Epidermal Growth Factor
epigallocatechin gallate (EGCG)
ergothioneine
fibroblast growth factor
fisetin
flavonoids
flaxseed
fo-ti
fucoxanthin
Gac
Gerovital H3
ginkgo biloba
Ginsenosides
Glabridin
goji berry
green tea
greens blend (proprietary)
Haematococcus pluvialis
hazelnut
HMB hydroxymethylbutyrate
hydroxymethylbutyrate
icariin
L-carnosine
lutein
Lycium
magnesium
Matcha
Melatonin
mixed carotenoids
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oolong tea
Peptides
Phytoene
Phytofluene
polypeptide complex (proprietary)
polyphenols
protein
pyrroloquinoline quinone
quercetin
resveratrol
Rhodiola
royal jelly
Salidroside
selenium
Shilajit
silicon
soy isoflavones
soybean
Squalene
Trans-pterostilbene
Tremella
Triterpenes
turmeric
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
Watermelon
Xanthophyll
Yerba mate
Zinc
β-nicotinamide mononucleotide (NMN)