Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rosmarinic acid, a polyphenolic compound found in herbs such as rosemary, basil, and perilla, has been studied for its potential anti-allergic effects, particularly in the context of respiratory allergies. Preclinical studies indicate that rosmarinic acid possesses anti-inflammatory and antioxidant properties, and it can inhibit the activation of immune cells such as mast cells and eosinophils involved in allergic responses. Several animal studies and in vitro research suggest that rosmarinic acid suppresses the production of inflammatory mediators like histamine and leukotrienes.

There is limited but notable clinical evidence as well. A randomized controlled trial published in 2004 (Osakabe et al., Clinical & Experimental Allergy) found that supplementation with perilla extract rich in rosmarinic acid reduced symptoms and markers of seasonal allergic rhinoconjunctivitis in humans. The study reported significant improvements in eye-related symptoms and in levels of neutrophils in nasal lavage fluid, supporting modest effectiveness for allergic respiratory symptoms. However, evidence is not yet robust, as the number of human studies is small, and most data come from preclinical research. Thus, while there is a scientific rationale and some early clinical support for the use of rosmarinic acid in respiratory allergies, more large-scale and rigorous human studies are needed to confirm its efficacy and safety.

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