Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, red wine, and certain berries, has been investigated for its potential role in supporting bone health and treating osteoporosis. Scientific interest in resveratrol arises from its antioxidant and anti-inflammatory properties, as well as its ability to modulate signaling pathways involved in bone metabolism. Preclinical studies in animal models and in vitro experiments have shown that resveratrol can stimulate osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) differentiation, potentially leading to increased bone formation and decreased bone resorption. These effects are thought to be mediated by the activation of SIRT1 (sirtuin 1) and the Wnt/β-catenin signaling pathway, both of which are involved in bone homeostasis.

However, clinical evidence in humans remains limited and inconclusive. Some small-scale clinical trials have suggested a modest benefit of resveratrol supplementation on bone mineral density or markers of bone turnover, particularly in postmenopausal women, but the results are not robust or widely replicated. Dosage, duration, and formulation differences further complicate interpretations. As such, while there is a scientific rationale and some preliminary evidence supporting resveratrol's use for osteoporosis, the overall quality and quantity of clinical data remain insufficient to strongly endorse its use as a primary or adjunct therapy for this condition.

More about resveratrol
More about Osteoporosis

Other ingredients used for Osteoporosis

Other health conditions supported by resveratrol

Products containing resveratrol

Nature's Sunshine Cardio Assurance
Nature's Sunshine Cholester-Reg II
Nature's Sunshine Nattozimes Plus
Nature's Sunshine Solstic Cardio
Nature's Sunshine Super ORAC