Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a flavonoid found in many fruits and vegetables and has attracted interest for its potential role in supporting bone health, including the prevention and treatment of osteoporosis. Scientific studies, primarily in vitro and in animal models, suggest that quercetin may have beneficial effects on bone metabolism. For example, quercetin appears to stimulate osteoblast (bone-forming cell) activity while inhibiting osteoclastogenesis (formation of bone-resorbing cells), potentially through modulation of oxidative stress and inflammation pathways. These effects are thought to be mediated by its antioxidant properties and its influence on signaling pathways such as the RANKL/OPG axis, which is crucial for bone remodeling.

However, direct clinical evidence in humans is limited. While some animal studies have shown that quercetin supplementation can prevent bone loss in models of osteoporosis (such as ovariectomized rats), large-scale, well-controlled human trials are lacking. The current scientific validation for quercetin’s use in osteoporosis is therefore preliminary and mostly preclinical. Nonetheless, its proposed mechanisms are biologically plausible and provide a rationale for further investigation. Overall, while there is some scientific basis for quercetin's use in osteoporosis, the evidence is not strong enough to recommend it as a primary treatment in clinical practice.

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