Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Plumbago zeylanica, commonly known as Ceylon leadwort, has a history of use in traditional medicine systems, such as Ayurveda, for a variety of ailments, including skin diseases. Its use against fungal infections is supported by some scientific evidence. Several in vitro studies have demonstrated that extracts of Plumbago zeylanica possess antifungal activity against various pathogenic fungi, including Candida albicans and several dermatophytes. The primary bioactive compound, plumbagin, is believed to contribute significantly to these effects by disrupting fungal cell walls and inhibiting fungal growth. However, most of the evidence is preclinical; studies have generally been limited to laboratory settings (petri dish experiments) and animal models, rather than rigorous human clinical trials. Traditional texts often cite its use for skin diseases and infections, which may include fungal etiologies, but do not specify antifungal action as clearly as modern pharmacological studies. Therefore, while there is some scientific support for the antifungal properties of Plumbago zeylanica, the overall evidence is limited and not robust enough to recommend its use as a stand-alone or primary antifungal treatment in clinical practice. More human studies are needed to confirm its efficacy and safety for treating fungal infections.

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