Synopsis

Source of validity: Traditional
Rating (out of 5): 1

The use of Melia (a genus that most commonly refers to Melia azedarach, also known as Chinaberry) for epilepsy is primarily rooted in traditional medicine. Historical records and ethnobotanical surveys indicate that various parts of the Melia plant have been employed in traditional systems, especially in South Asian and some African folk remedies, to manage neurological conditions, including epilepsy and convulsions. The purported anticonvulsant effects are likely based on observations and anecdotal reports rather than systematic trials.

However, scientific validation for its efficacy is extremely limited. A few preclinical studies have examined extracts from Melia azedarach for neuropharmacological effects, but there is no robust evidence from clinical trials supporting its use in epilepsy. Furthermore, some components of the plant are known to be toxic, raising safety concerns. Major pharmacopoeias and clinical guidelines do not endorse Melia for epilepsy treatment, and its use persists mainly in traditional or folk settings. The evidence, therefore, is rated at 1, indicating anecdotal or historical references with little to no scientific support.

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