Evidence supporting the use of: L-proline
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-proline is an amino acid with a well-established role in collagen synthesis, which is crucial for wound healing and tissue repair following surgery. Collagen is the primary structural protein in connective tissue, and its production relies in part on the availability of proline. Some studies have demonstrated that proline supplementation may enhance collagen formation and potentially support wound healing, particularly in situations where nutritional intake is compromised, such as in elderly or malnourished patients.

However, the direct scientific evidence supporting the use of L-proline supplements specifically for routine post-surgical healing in otherwise healthy adults is limited. Most individuals obtain sufficient proline through dietary protein, and the body can synthesize proline endogenously from other amino acids. Clinical trials directly evaluating L-proline supplementation for post-surgical outcomes in humans are sparse, and most data derive from animal studies or in vitro research.

In summary, while there is a strong biochemical rationale and some indirect or preliminary evidence supporting the role of L-proline in surgical healing, robust clinical evidence in humans is lacking. Therefore, L-proline supplementation is sometimes used in clinical nutrition or specialized medical foods, but its routine use for surgical recovery is not universally recommended without specific indications.

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