Evidence supporting the use of: L-arginine
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-arginine is an amino acid that serves as a precursor to nitric oxide (NO), a molecule that helps dilate blood vessels and improve blood flow. The rationale for using L-arginine in angina stems from its role in promoting vasodilation, potentially increasing oxygen delivery to the heart muscle and reducing chest pain. Early laboratory and small clinical studies indicated that L-arginine supplementation could improve endothelial function and reduce angina symptoms, fostering scientific interest in its therapeutic potential.

However, larger and more rigorous clinical trials have yielded inconsistent results. Some studies have shown modest improvements in exercise tolerance and symptom relief in patients with stable angina. Others, including a pivotal 2006 trial published in JAMA, found no benefit—and even potential harm—in post-myocardial infarction patients taking L-arginine. The American Heart Association and other major cardiovascular societies do not currently recommend L-arginine supplementation for angina due to insufficient evidence of efficacy and possible safety concerns.

In summary, while the use of L-arginine for angina has a scientific rationale and some supporting evidence, the overall quality and consistency of clinical data are weak. The evidence supports a low-to-moderate level of confidence (2/5) in its efficacy for angina treatment, and routine use is not advised.

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