Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycosaminoglycans (GAGs), such as hyaluronic acid (HA) and dermatan sulfate, are polysaccharides naturally present in the extracellular matrix of the skin and play a role in wound healing and tissue repair. There is modest scientific evidence supporting their use in the management of scars and scar tissue, primarily due to their involvement in modulating inflammation, promoting hydration, and influencing fibroblast activity during the healing process. Several preclinical studies and limited clinical trials have shown that topical or injectable forms of GAGs, especially hyaluronic acid, can improve wound healing and reduce scar formation by enhancing tissue regeneration and maintaining proper extracellular matrix structure. For example, hyaluronic acid-based dressings are sometimes used in clinical practice to manage wounds and surgical incisions, with some studies demonstrating improved healing rates and more favorable cosmetic outcomes. However, robust, high-quality randomized controlled trials specifically examining GAGs for established scar treatment are limited, and the evidence for their effectiveness in remodeling mature scar tissue is not strong. Other GAGs, such as chondroitin sulfate, have been less studied in this context. In summary, while there is some scientific rationale and preliminary evidence for the use of GAGs in supporting wound healing and possibly reducing scar formation, the evidence base is not strong or conclusive, and further research is needed to firmly establish their therapeutic role in scar treatment.

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