Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycodeoxycholic acid is a conjugated bile acid derived from deoxycholic acid and glycine. Bile acids and their derivatives have been studied for their capacity to dissolve cholesterol gallstones, which are the most common type of gallstones. The most widely used and studied bile acids for this purpose are ursodeoxycholic acid (UDCA) and, to a lesser extent, chenodeoxycholic acid (CDCA). Glycodeoxycholic acid, as a naturally occurring bile acid in the human body, is a minor component compared to these but is part of the overall bile acid pool.

There is scientific rationale for the use of bile acids in gallstone dissolution: they reduce cholesterol saturation in bile and can gradually dissolve cholesterol stones. However, glycodeoxycholic acid specifically is rarely used as a direct therapeutic agent for gallstones. Most clinical trials and medical guidelines focus on UDCA or CDCA due to their efficacy and safety profiles. Some in vitro and animal studies indicate that glycodeoxycholic acid may contribute to cholesterol solubilization, but robust clinical evidence for its use as a standalone treatment in humans is limited.

In summary, while the class of bile acids is scientifically validated for gallstone dissolution, glycodeoxycholic acid itself is not a primary agent and evidence for its specific use is moderate at best. The rating reflects its role as part of the bile acid pool rather than as a distinct, clinically validated treatment.

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