Synopsis

Source of validity: Scientific
Rating (out of 5): 3

D-mannose is a naturally occurring simple sugar that has garnered significant attention as a supplement for the prevention and management of urinary tract infections (UTIs), particularly recurrent UTIs in women. The scientific rationale for its use is based on its mechanism of action: D-mannose inhibits the adhesion of uropathogenic Escherichia coli (E. coli) to the urothelial cells lining the urinary tract. E. coli, the most common causative agent of UTIs, attaches to these cells via fimbriae that recognize mannose residues. Supplemental D-mannose saturates these binding sites, effectively preventing bacterial colonization and facilitating bacterial elimination in the urine.

Clinical studies provide moderate evidence supporting the efficacy of D-mannose in reducing the recurrence of UTIs. Several randomized controlled trials (RCTs) have demonstrated that D-mannose supplementation is associated with a significantly lower risk of recurrent UTIs compared to placebo and may be comparable in efficacy to antibiotics, but with fewer side effects. For example, a 2014 RCT published in the "World Journal of Urology" found that D-mannose was as effective as nitrofurantoin in preventing recurrences over six months. Systematic reviews also highlight its favorable safety profile.

While more large-scale trials are needed for definitive guidance, current evidence justifies the use of D-mannose as a non-antibiotic preventive strategy for recurrent UTIs. However, it is not intended for acute UTI treatment or for complicated cases, and patients should consult healthcare providers before use.

More about D-mannose
More about Urinary Tract Infections

Other ingredients used for Urinary Tract Infections

Other health conditions supported by D-mannose

Products containing D-mannose