Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Butyric acid, a short-chain fatty acid produced by the fermentation of dietary fibers in the colon, has garnered scientific interest for its potential role in supporting gut health, including conditions like Leaky Gut Syndrome (increased intestinal permeability). Several preclinical studies (mostly in animal models and in vitro) demonstrate that butyric acid can enhance the integrity of the intestinal barrier by promoting the expression of tight junction proteins, reducing inflammation, and supporting the health of colonic epithelial cells. For example, butyrate supplementation has been shown to decrease intestinal permeability and inflammation in mouse models of colitis. Additionally, some small human studies and clinical trials have examined oral butyrate supplementation in patients with inflammatory bowel disease and irritable bowel syndrome, with mixed but generally positive effects on symptoms and markers of gut health. However, direct, large-scale clinical evidence specifically linking butyric acid supplementation to significant improvement in Leaky Gut Syndrome in humans is limited. Much of the rationale for its use comes from its established role in maintaining gut barrier function and its anti-inflammatory properties, rather than robust clinical trials in patients with Leaky Gut Syndrome per se. In summary, while there is a scientific rationale and some preliminary evidence supporting the use of butyric acid for gut barrier support, high-quality human data are lacking, so the evidence is moderate (rated 3/5).

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