Evidence supporting the use of: Barberry
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Barberry (Berberis vulgaris) has a long history of use in traditional medicine systems, particularly in Ayurveda, Traditional Chinese Medicine, and various folk healing practices. Its use against intestinal parasites and worms (nematodes) is primarily based on the presence of berberine, a prominent isoquinoline alkaloid found in the root and bark. Traditional healers have administered barberry extracts to treat gastrointestinal complaints believed to be caused by parasitic infections. Historical records and ethnobotanical surveys cite its application for clearing "worms" and purifying the digestive tract. However, while there is a strong traditional precedent, scientific validation remains limited.

Some modern in vitro studies suggest that berberine exhibits antiparasitic and antimicrobial activities, including efficacy against certain protozoa and helminths. However, these findings are preliminary and often not specific to barberry whole extracts, but rather to isolated berberine or related compounds. Clinical trials in humans specifically evaluating barberry or its extracts for nematode or worm infections are scarce or lacking. Thus, current evidence supporting barberry's effectiveness against intestinal parasites is largely traditional, with only modest support from laboratory research and no robust clinical validation.

In summary, the use of barberry for treating parasites is rooted in tradition, with a moderate historical reputation but only early-stage scientific support. The evidence rating reflects the gap between traditional use and conclusive modern research.

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