Evidence supporting the use of: Ashwagandha
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ashwagandha (Withania somnifera) has limited but growing scientific evidence supporting its potential role in osteoporosis management. Preclinical studies, mainly in animal models, suggest that ashwagandha extracts may have positive effects on bone health. For example, some rodent studies have shown that ashwagandha can increase bone mineral density and improve bone microarchitecture in models of osteoporosis induced by ovariectomy (a standard method to mimic postmenopausal osteoporosis). The proposed mechanisms involve its antioxidant, anti-inflammatory, and adaptogenic properties, as well as its potential to modulate hormones and reduce cortisol levels, which may indirectly support bone formation and reduce bone resorption.

However, human clinical data are sparse. There are no robust, large-scale clinical trials directly assessing ashwagandha’s effects on osteoporosis in humans. Most of the evidence is preclinical or comes from in vitro studies indicating that withanolides (active compounds in ashwagandha) may stimulate osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) activity. Additionally, some traditional Ayurvedic medicine formulations use ashwagandha to promote vitality, which may incidentally support bone health, but osteoporosis-specific claims are not well documented in traditional texts.

In summary, while early data are promising and provide a rationale for further research, the current scientific evidence supporting ashwagandha’s use for osteoporosis is preliminary, meriting a low-to-moderate rating (2/5) at this time.

More about ashwagandha
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc

Other health conditions supported by ashwagandha

Addictions (drugs)
Addictions (general remedies for)
Afterbirth Pain
Aging (prevention)
Alcoholism
Allergies (respiratory)
Alzheimer's Disease
Amenorrhea
Anemia
Anger (excessive)
Angina
Anorexia
Anxiety
Anxiety Disorders
Appetite (deficient)
Arthritis
Asthma
Athletic and Exercise Aids
Attention Deficit Disorder
Autoimmune Disorders
Backache
Bedwetting
Body Building
Cancer (prevention)
Cancer Treatment (reducing side effects)
Emotional Sensitivity
Endurance (lack of)
Energy (lack of)
Epilepsy
Erectile Dysfunction
Exercise
Fatigue
Fear (excessive)
Fibromyalgia Syndrome
Goiter
Grief and Sadness
Hair (graying)
Hair (loss or thinning)
Hair Care (general)
Headache (general)
Headache (tension)
Heart (weakness)
Hot Flashes
Hypertension
Hypothyroid
Hysteria
Infertility
Inflammation
Insomnia
Irritability
Leucorrhea
Lyme Disease
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Miscarriage (prevention)
Mood Swings
Muscle Tone (lack of)
Nervous Exhaustion
Nervousness
Neurosis
Nightmares
Nocturnal Emission
Obsessive Compulsive Disorder
Pain (general remedies for)
Parkinson's Disease
Peripheral Neuropathy
Pets (supplements for)
PMS (general)
PMS Type C
PMS Type D
Post Partum Depression
Post Partum Weakness
Post Traumatic Stress Disorder
Premature Ejaculation
Prolapsed Uterus
Sex Drive (low)
Sleep (restless and disturbed)
Stress
Syphilis
Tension
Testosterone (low)
Thinking (cloudy)
TMJ
Tremors
Triglycerides (high)
Tuberculosis
Vitiligo
Weight Gain
Weight Loss
Worry
Adrenal Fatigue
Cancer (natural therapy for)
Cholesterol (high)
Circulation (poor)
Concentration (poor)
Depression
Diabetes
Digestion (poor)
Migraine
Osteoporosis
Rheumatoid Arthritis
Wounds and Sores
Chronic Obstructive Pulmonary Disorder