Evidence supporting the use of: Vitamin E
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been investigated for its potential role in supporting or treating arteriosclerosis (hardening and narrowing of the arteries due to plaque buildup), primarily because of its antioxidant properties. Vitamin E, particularly in the form of alpha-tocopherol, can scavenge free radicals and reduce oxidative stress, which is believed to contribute to the development of atherosclerosis (a major form of arteriosclerosis). Early observational studies suggested that higher vitamin E intake or supplementation might correlate with a reduced risk of cardiovascular disease, leading to widespread public and medical interest.

However, large-scale randomized controlled trials (RCTs) have not consistently shown that vitamin E supplementation provides significant cardiovascular protection. Notable studies such as the Heart Outcomes Prevention Evaluation (HOPE) and the Women's Health Study found no significant benefit of vitamin E supplements in reducing cardiovascular events or slowing the progression of arteriosclerosis. Some evidence even points to potential risks with high-dose supplementation, such as increased risk of hemorrhagic stroke.

In summary, while the theoretical rationale for using vitamin E to support arteriosclerosis is grounded in science (antioxidant effects), clinical outcomes from robust studies have not validated its efficacy. Therefore, current guidelines do not recommend vitamin E supplementation specifically for the prevention or treatment of arteriosclerosis. Its use for this purpose is considered to have weak scientific support and is not part of mainstream clinical practice.

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