Evidence supporting the use of: Resveratrol
For the health condition: Cystic Fibrosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes and berries, has been studied for its potential therapeutic effects in Cystic Fibrosis (CF). The interest in resveratrol for CF stems primarily from preclinical scientific research rather than traditional use. CF is characterized by defects in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to thick, sticky mucus in multiple organs. In vitro and animal studies have shown that resveratrol may stimulate chloride secretion via alternative channels and may enhance the function of some mutant forms of CFTR. For example, a study published in American Journal of Physiology-Lung Cellular and Molecular Physiology (2007) demonstrated that resveratrol could activate alternative chloride channels in CF airway epithelia, potentially improving airway hydration. Other research suggests that resveratrol’s anti-inflammatory and antioxidant properties might help mitigate lung inflammation in CF. However, human clinical data are very limited. There are no large, well-controlled trials confirming significant clinical benefit in people with CF. Most evidence comes from cell line and animal models, and the translation to clinical outcomes is uncertain. Thus, while the rationale for use is grounded in scientific exploration and some laboratory evidence, the current strength of evidence for its use in CF is weak, warranting a rating of 2 out of 5. Until more robust clinical trials are completed, resveratrol should not be considered a proven therapy for CF.

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Other ingredients used for Cystic Fibrosis

green tea
quercetin
resveratrol
vitamin C
vitamin D
Zinc