Evidence supporting the use of: Resveratrol
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found predominantly in grapes and red wine, has been investigated for its potential cardiovascular benefits, including its use in supporting or treating angina. The scientific rationale for its use is based on preclinical and some early clinical studies suggesting that resveratrol possesses antioxidative, anti-inflammatory, and vasodilatory properties. These properties could theoretically improve endothelial function, reduce oxidative stress, and enhance nitric oxide production, thereby potentially alleviating some symptoms associated with angina—namely, reduced blood flow to cardiac tissues. However, while there is a plausible biological basis and some supportive animal data, the direct evidence in humans, specifically for the treatment or prevention of angina, is limited. Most human studies have focused on surrogate endpoints such as endothelial function, blood pressure, or markers of oxidative stress, rather than on clinical outcomes like reduced angina frequency or severity. A few small clinical trials have shown improvements in blood flow and endothelial function in people with cardiovascular risk factors, but these have not consistently translated to demonstrated benefits for angina symptoms. In summary, while there is a scientific rationale and some early evidence suggesting potential cardiovascular benefits of resveratrol, robust clinical data specifically supporting its use for angina is lacking. The current evidence base rates as low to moderate (2/5), reflecting promising but unproven benefits in this context.

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