Evidence supporting the use of: Quercetin
For the health condition: Conjunctivitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in many fruits and vegetables, has attracted scientific interest for its potential role in managing conjunctivitis, particularly allergic conjunctivitis. The primary rationale stems from quercetin’s anti-inflammatory and anti-allergic properties, which have been demonstrated in laboratory and some animal studies. Quercetin is known to inhibit the release of histamine and pro-inflammatory cytokines from mast cells and basophils, both key mediators in allergic responses that contribute to conjunctival irritation and inflammation.

Some small-scale clinical studies and in vitro experiments suggest quercetin may reduce symptoms such as redness, itching, and swelling associated with allergic conjunctivitis. For example, topical quercetin formulations have shown symptomatic improvement in animal models and, to a lesser extent, in human pilot trials. However, the overall quality and quantity of clinical evidence remains limited, with most studies being preliminary, underpowered, or lacking robust controls. No large-scale, high-quality randomized controlled trials have definitively established quercetin’s efficacy for conjunctivitis in humans.

In summary, while there is a plausible scientific basis and early experimental support for quercetin’s use in managing allergic conjunctivitis, the clinical evidence is still emerging and insufficient for strong recommendations. The evidence rating of 2 reflects preliminary support, but more rigorous studies are needed to confirm its effectiveness and safety.

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