Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Resveratrol is a polyphenolic compound found in grapes, berries, and peanuts, and has been studied for its effects on mitochondrial function. Scientific interest in resveratrol’s impact on mitochondria is largely based on preclinical (animal and cell-based) studies suggesting that it can activate sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK), which are pathways implicated in mitochondrial biogenesis and function. These pathways are associated with improved energy metabolism, increased mitochondrial number, and better mitochondrial efficiency. Animal studies have shown that resveratrol supplementation can enhance mitochondrial function and protect against mitochondrial dysfunction in various models of metabolic and neurodegenerative diseases.

However, clinical evidence in humans is less robust. Some small trials have reported mild improvements in markers of mitochondrial function, insulin sensitivity, and muscle metabolism with resveratrol supplementation, but results are inconsistent and often limited by small sample sizes and short durations. Systematic reviews and meta-analyses generally conclude that while resveratrol shows promise for supporting mitochondrial health, more high-quality human trials are needed to confirm its efficacy and optimal dosing.

Overall, there is scientific rationale and preliminary evidence supporting the use of resveratrol for mitochondrial health, but the strength of evidence is moderate (3/5) due to a lack of large, well-controlled human studies. Resveratrol is not a traditional remedy for mitochondrial issues, and its use in this context is a product of recent scientific investigation.

More about resveratrol
More about Mitochondria

Other ingredients that support Mitochondria

Other body systems supported by resveratrol

Products containing resveratrol

Nature's Sunshine Cardio Assurance
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Nature's Sunshine Nattozimes Plus
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Nature's Sunshine Super ORAC