Pycnogenol is a standardized extract from the bark of the French maritime pine tree (Pinus pinaster). It is rich in procyanidins, bioflavonoids, and phenolic acids, which have antioxidant and anti-inflammatory properties. Several clinical studies have investigated Pycnogenol’s effects on capillary and vascular health, with a focus on microcirculation and capillary fragility.

Research has demonstrated that Pycnogenol can strengthen capillary walls, reduce capillary permeability, and improve symptoms associated with chronic venous insufficiency and edema. For example, a 2002 randomized controlled trial in Angiology found that Pycnogenol reduced leg swelling and improved microcirculatory function in patients with chronic venous insufficiency. Another study published in Phytomedicine (2001) showed that Pycnogenol supplementation reduced capillary leakage in hypertensive patients.

The mechanism appears to involve Pycnogenol’s ability to protect endothelial cells from oxidative stress and inflammation, thereby maintaining capillary integrity. However, while the evidence is promising and better than most plant extracts for this body system, the number of large, high-quality trials is still limited.

In summary, there is moderate scientific evidence supporting the use of Pycnogenol for capillary health, particularly in improving microcirculation and reducing capillary fragility, justifying a mid-level evidence rating.