Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Macaenes, derived from the root of the Lepidium meyenii plant (commonly known as maca), are long-chain fatty acid derivatives that are considered among the bioactive compounds present in maca. Maca has a long history of traditional use in the Andes, particularly for enhancing fertility, sexual function, and supporting overall female reproductive health. Historical records and ethnobotanical surveys show that Andean populations have used maca root to address issues such as irregular menstruation, menopausal symptoms, and to boost libido in women. The justification for maca’s use in these contexts is therefore rooted in tradition rather than robust modern scientific validation specifically for macaenes. While some contemporary studies have explored the effects of maca root extracts on sexual function and menopausal symptoms, the evidence remains limited and often of low methodological quality. Most studies do not isolate macaenes specifically, and those that do are preliminary, with small sample sizes and inconsistent results. Reviews and systematic analyses generally conclude that more rigorous research is needed. Thus, while there is a well-established traditional basis for using maca and its constituents, including macaenes, to support the female reproductive system, scientific validation—particularly for macaenes alone—remains weak.

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