Luffa (also spelled loofah or luffah) is a plant whose dried fibrous skeleton is commonly used as a natural scrubber, but various parts of the plant have a long history of use in traditional medicine, especially in Asia and parts of Europe. In traditional European herbalism and in homeopathy, Luffa operculata has been used as a remedy for sinus congestion, allergic rhinitis, and other sinus-related issues. The traditional use is notable in Germany, where Luffa extracts are included in some herbal nasal sprays and remedies intended for sinus health. The rationale behind its use is based on anecdotal reports and historical practice, suggesting anti-inflammatory and decongestant effects.

However, there is limited scientific validation for these claims. A few small laboratory and animal studies have examined possible anti-inflammatory or mucolytic effects of Luffa extracts, but clinical trials in humans are sparse, of low quality, or inconclusive. No major clinical guidelines endorse Luffa for sinus health. Thus, while its use is primarily rooted in tradition, there is insufficient scientific evidence to confidently support its effectiveness for the sinuses, and the quality of available evidence is low. Users should approach such remedies with caution and seek medical advice for persistent sinus issues.