Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Honokiol is a bioactive compound extracted from the bark and leaves of Magnolia species, long used in traditional Asian medicine for its calming properties. Recent scientific research has investigated Honokiol’s effects on the GABAergic system, which is the main inhibitory neurotransmitter system in the central nervous system and is involved in regulating anxiety, sleep, and muscle relaxation. Several preclinical studies have demonstrated that Honokiol can act as a positive modulator of GABA_A receptors, enhancing GABAergic neurotransmission. For example, a 2012 study in Neuropharmacology found that Honokiol could increase GABA-induced currents in cultured hippocampal neurons and produce anxiolytic and sedative effects in animal models comparable to certain benzodiazepines, but with a more favorable side effect profile. Other studies have confirmed similar GABAergic activity and associated behavioral effects, such as reduced anxiety and improved sleep in rodents. However, while these findings are promising, most of the evidence to date is limited to animal studies and in vitro models; robust human clinical trials are still lacking. Thus, while Honokiol’s ability to support the GABA system is supported by scientific (albeit preclinical) evidence, further research is needed to confirm efficacy and safety in humans.

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