Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fungal enzyme blends, typically derived from species like Aspergillus oryzae and Aspergillus niger, are widely used as supplemental digestive enzymes. Their primary components—proteases, lipases, and amylases—are similar to the enzymes naturally secreted by the pancreas to digest proteins, fats, and carbohydrates. The rationale for using fungal enzyme blends to "support" the pancreas relates to their ability to supplement or partially replace endogenous pancreatic enzymes, especially in cases of pancreatic insufficiency such as chronic pancreatitis or cystic fibrosis. Several clinical studies and reviews suggest that supplemental digestive enzymes can improve nutrient absorption and gastrointestinal symptoms in patients with exocrine pancreatic insufficiency. Fungal-derived enzymes are particularly valued because they remain active across a broader pH range than animal-sourced enzymes, potentially enhancing their effectiveness in the digestive tract.

However, while there is scientific validation for the use of digestive enzyme supplementation in states of pancreatic insufficiency, evidence for benefits in people with normal pancreatic function or for direct "support" of pancreatic health in healthy individuals is limited. Most clinical research focuses on symptom relief and nutrient absorption in deficiency states, rather than prevention or enhancement of pancreatic function. Therefore, while the use of fungal enzyme blends is scientifically justified in certain clinical contexts, the broader claim of "pancreas support" in healthy individuals is not robustly supported by current evidence.

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