Evidence supporting the use of: Cohosh
For the body system: Female Reproductive System

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Cohosh, particularly Black Cohosh (Actaea racemosa, formerly Cimicifuga racemosa), has a long history of traditional use in supporting the female reproductive system. It has been used by Native American communities and later by Western herbalists primarily for alleviating symptoms associated with menopause, such as hot flashes, mood swings, and menstrual irregularities. The herb’s popularity increased in the 19th century and it became a common ingredient in patent medicines for "female complaints."

Scientific evidence for Black Cohosh's effectiveness is mixed. Some clinical trials suggest modest benefit for menopausal symptoms, particularly hot flashes and sleep disturbances, but meta-analyses and systematic reviews indicate that the effects are inconsistent and not robust across studies. The precise mechanism of action remains unclear, as Black Cohosh does not appear to have estrogenic effects in the body, contrary to early assumptions. Instead, it may act on serotonin receptors, which could explain its impact on mood and thermoregulation. Safety data indicate that short-term use is generally well-tolerated, but there have been rare reports of liver toxicity.

Overall, while Cohosh’s use is primarily justified by tradition and historical precedent, there is some, though not strong, scientific evidence supporting its role in managing certain menopausal symptoms. Its use for broader female reproductive health (such as fertility or cycle regulation) has less scientific backing.

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Other ingredients that support Female Reproductive System

25-d-spirosta-3, 5-diene
27-deoxyactein
7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abuta
Agnuside
AHCC
Alchemilla
Aletris
amino acids
anamu
anemarrhena asphodeloides
Anemone
Angelica
animal protein
anise
Anserina
Ashoka
ashwagandha
barbasco
basil
Belamcanda
bethroot
betony
bird\'s nest
black cohosh
blessed thistle
blue cohosh
borage oil
broccoli
bugbane
Caesalpinia crista
Calochortus
casticin
Ceylon leadwort
chaste tree
Chinese pond turtle
Chlorophytum
Clary sage
Cnidium
cohosh
cramp bark
Crinum latifolium
Cynomorium
d-alpha tocopherol
daidzein
damiana
dandelion
date
DHEA
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dioscorea
diosgenin
dodder
dong quai
dong quai root
egg
eleuthero
equol (proprietary)
Erythrina
estrogen
evening primrose oil
evening primrose oil
false unicorn root
fatty acids
fennel
fenugreek
flaxseed
fo-ti
folate
folic acid
formononetin
furostanols
gamma linolenic acid (GLA)
genistein
giant trillium
ginger
Ginsenosides
goat\'s rue
golden ragwort
goldenseal
guelder rose
herbal blend (proprietary)
hibiscus
HMR lignan
horny goat weed
Hypericum
Indian fagonia
Indian tinospora
indole-3-carbinol
inositol
inositol phosphate
isoflavones
jasmine
jujube
Kigelia africana
Labisia pumila
labrador tea
Lactobacillus acidophilus
Lactobacillus crispatus
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus jensenii
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lady's Mantle
Laminaria
Leptadenia
lignans
ligustilides
lingzhi
linoleic acid (LA)
lipids
Loranthus
maca
macaenes
macamides
mandrake
Marine lipid
Miroestrol
Montanoa tomentosa
Motherwort
Mugwort
Nettle
Nigella seed
omega-3 fatty acids
Pennyroyal
peony
Phytoestrogens
polyunsaturated fat
Puerain
Pulsatilla
raspberry
red clover
rose
rose oil
royal jelly
Rubia cordifolia
Rubus
rue
Safed musli
saffron
selenium
Shataverins
shepherd's purse
Sichuan Lovage
Soy
soy isoflavones
Soy Protein
soybean
Sparganium
spearmint leaf
squawvine
Szechuan lovage
Taxillus chinensis
trace minerals
tribulus
turmeric
Vervain
Viburnum
vitamin B
vitamin B6
vitamin E
Vitex Agnus-Castus
Vitexicarpin
White Dead Nettle Flower
Wild yam
Wood betony
Yarrow
Yarrow

Products containing cohosh