Synopsis

Source of validity: Traditional
Rating (out of 5): 2

California poppy (Eschscholzia californica) has a long history of traditional use as a calming and sedative herb among Native American groups and later herbal practitioners in North America. Historically, the aerial parts of the plant have been used in teas and tinctures to promote relaxation, reduce mild pain, and aid sleep. This traditional use aligns with the idea of supporting the "GABA body system," as GABA (gamma-aminobutyric acid) is the brain’s primary inhibitory neurotransmitter and is involved in relaxation and sedation. Some in vitro and animal studies suggest that alkaloids present in California poppy, such as protopine and californidine, may interact with GABA_A receptors and show mild anxiolytic and sedative effects. However, robust clinical trials in humans are lacking, and the precise mechanism of action remains unclear. Thus, the use of California poppy for GABA system support is primarily justified by tradition, with limited scientific evidence supplementing its reputation. The strength of the evidence is therefore rated as 2 out of 5, reflecting a strong historical basis but limited clinical validation.

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