Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Alpha glyceryl (most commonly referring to Alpha-GPC, or alpha-glycerylphosphorylcholine) is a compound used as a source of choline, an essential nutrient and precursor for the neurotransmitter acetylcholine. Scientific evidence supports its use for supporting the "Specific Neurotransmitters" body system, particularly cognitive functions that depend on acetylcholine, such as memory and learning. Alpha-GPC has been shown in multiple human clinical trials to increase acetylcholine levels in the brain and enhance cognitive performance, especially in populations with cognitive decline.

Randomized controlled trials have demonstrated that Alpha-GPC supplementation can improve memory and attention in patients with dementia and Alzheimer’s disease. For example, a 1994 multicenter trial published in "Clinical Therapeutics" found that Alpha-GPC improved cognitive symptoms in patients with mild to moderate Alzheimer’s disease. Other studies have demonstrated benefits in cognitive recovery after stroke.

While Alpha-GPC is not typically used in traditional herbal medicine, its efficacy is well-supported by modern pharmacological and clinical research. The ingredient is also generally recognized as safe, though further research is ongoing to fully understand its long-term effects. Overall, Alpha-GPC is among the best-validated choline sources for supporting acetylcholine-mediated neurotransmitter systems, with a substantial body of scientific evidence supporting its role in cognitive health.

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