Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Devil's claw (Harpagophytum procumbens) is a plant native to southern Africa, traditionally used for its anti-inflammatory and analgesic properties. Its use to support the structural system—meaning bones, joints, muscles, and connective tissues—has a scientific basis, primarily for conditions involving joint pain, such as osteoarthritis and low back pain.

Several clinical studies and systematic reviews have evaluated devil's claw extracts, particularly those standardized to contain harpagoside, its primary active compound. Evidence suggests that devil's claw can modestly reduce pain and improve mobility in people with osteoarthritis of the knee and hip. A 2016 review in the journal Planta Medica concluded that devil's claw is more effective than placebo and comparable to some non-steroidal anti-inflammatory drugs (NSAIDs) for pain relief, with fewer adverse effects. The European Medicines Agency recognizes devil's claw as a traditional herbal medicinal product for the relief of minor joint pain.

However, not all studies report significant clinical benefits, and methodological quality varies. Most evidence supports its use for symptom management (pain and inflammation) rather than for structural regeneration or disease modification. The overall evidence base is moderate, justifying a rating of 3 out of 5. Long-term safety data are limited, but short-term use appears to be well tolerated. As always, patients should consult healthcare providers before starting new supplements, especially if they have underlying health conditions or are taking medications.

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Products containing devil's claw

Nature's Sunshine Devil's Claw
Nature's Sunshine Nerve Eight
Nature's Sunshine Nervous System (30 Day Program)