Picrorhiza kurroa, commonly known as Kutki, has a long history of use in traditional Ayurvedic and Unani medicine, especially for liver and biliary disorders, which include support for the gall bladder. In these traditional systems, it is prized for its purported ability to "cool" the liver, stimulate bile flow, and help manage conditions like jaundice, hepatitis, and cholecystitis (inflammation of the gall bladder). The roots and rhizomes of Picrorhiza kurroa contain iridoid glycosides such as picroside I and II, which are thought to contribute to its therapeutic effects.

While there are a number of modern scientific studies exploring the hepatoprotective (liver-protecting) effects of Picrorhiza kurroa, direct clinical evidence supporting its specific benefits for gall bladder health is limited. Most research focuses on its antioxidant, anti-inflammatory, and bile-stimulating effects in animal models or in vitro. These actions may indirectly support the gall bladder by enhancing bile production and flow, potentially reducing the risk of gallstones or biliary stasis. However, robust clinical trials in humans specifically targeting gall bladder outcomes are lacking.

In summary, the use of Picrorhiza kurroa for gall bladder support is primarily justified by traditional use, with some mechanistic scientific rationale but insufficient direct clinical evidence. Its role in promoting bile production and supporting liver function may underlie its historic reputation for supporting the gall bladder.