Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Arteries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacin (vitamin B3) has substantial scientific validation for supporting arterial health, particularly in the context of cardiovascular disease risk factors. Niacin is well-documented to have lipid-modifying effects: it lowers total cholesterol, low-density lipoprotein (LDL) cholesterol, and, most notably, triglycerides, while raising high-density lipoprotein (HDL) cholesterol. These effects were first described in mid-20th century clinical studies and have since been replicated in multiple large trials. Niacin’s ability to favorably alter lipid profiles led to its use as a therapeutic agent in the management of dyslipidemia and the prevention of atherosclerosis, a major arterial disease.

However, more recent studies, such as the AIM-HIGH and HPS2-THRIVE trials, have questioned whether niacin's lipid changes translate into significant reductions in cardiovascular events when added to statin therapy. While older studies did show benefit in reducing events such as myocardial infarction, more contemporary research suggests that the incremental benefit may be limited when modern therapies are in use. Despite these nuances, niacin’s direct effects on arterial risk factors are well-established, and it remains scientifically valid to state that niacin supports arterial health via cholesterol and triglyceride modulation, even if the translation to clinical outcomes is complex.

Common side effects, including flushing and hepatotoxicity at high doses, have limited widespread use. Nonetheless, the scientific evidence supporting niacin’s impact on arterial risk factors is robust, justifying a high evidence rating.

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