Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Liquid liver fractions, derived from animal liver (often bovine), have a history of use in traditional medicine and early 20th-century nutritional therapy. The rationale for their use in supporting mitochondrial function is primarily based on the liver’s high nutrient content, especially B vitamins, iron, CoQ10, and other cofactors essential for cellular energy production. These nutrients are involved in mitochondrial processes like the electron transport chain and ATP synthesis. However, while liver is indeed nutrient-dense, there is limited direct scientific research specifically linking liquid liver fractions to enhanced mitochondrial function in humans.

The tradition stems from a time when organ extracts were used as “tonics” to boost energy and vitality, especially before the era of modern supplements. Some historical reports and anecdotal evidence suggest benefits in fatigue and anemia, but rigorous clinical trials are lacking. Modern science recognizes the importance of nutrients found in liver for mitochondrial health, but studies typically focus on isolated nutrients rather than whole liver extracts. Therefore, while there is a logical basis and historical precedent, scientific validation for the specific use of liquid liver fractions to support mitochondria is weak.

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