Evidence supporting the use of: Choline
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Choline is an essential nutrient that serves as a precursor for the neurotransmitter acetylcholine, which plays a central role in the parasympathetic nervous system (PNS). The PNS is responsible for "rest and digest" activities in the body, and acetylcholine is its primary neurotransmitter, mediating responses such as decreased heart rate and increased digestive activity. Scientific evidence shows that adequate choline intake is necessary for the synthesis of acetylcholine. Deficiency in choline can lead to reduced acetylcholine levels, potentially impairing parasympathetic nervous function. However, most evidence supporting choline supplementation relates to its role in cognitive function, liver health, and fetal development, with fewer direct studies on its effect on the PNS in healthy adults. Still, the biochemical pathway connecting choline and acetylcholine is well established, providing a mechanistic rationale for choline's role in supporting the parasympathetic nervous system. Clinical trials directly linking choline supplementation to enhanced parasympathetic function are limited, so while the scientific basis is sound, the clinical evidence is moderate.

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