Methyl Combo
What's inside
Supplement Facts
| Amount Per Serving | |
|---|---|
| folate | 1333 mcg DFE |
| vitamin B12 sourced from methylcobalamin | 1000 mcg |
Recommended use
Take 1 vegcap twice daily, or as directed by your healthcare practitioner.
Days supply
30 days
UPC
099904216891
Product categories
Health conditions
Body systems
Expiration date
04/2027
How it works
In its natural form, folic acid has to pass through four enzymatic conversions before becoming the biologically active form of methyl folate known as methyltetrahydrofolate. Similarly, vitamin B12 has to pass through three enzymatic conversions before becoming the active form methylcobalamin. A 2008 study by the World Health Organization concluded that, “…deficiencies of [Folate and Vitamin B12] may be a public health problem that could affect many millions of people throughout the world.” Methyl Combo bypasses these conversion processes and delivers the active forms of B12 and Folic Acid, methylcobalamin and methylfolate. When these two influential vitamins are in their bioavailable state, they pair up and contribute to the methionine synthesis cycle. This cycle takes the Methyl Combo vitamins and creates methionine, an essential amino acid. Methionine is required for the healthy function of cells, proteins, enzymes, neurotransmitters, metabolic function, etc.
Why take this product?
- ✓Contributes to the maintenance of normal neurological and psychological functions*
- ✓Contributes to a reduction in tiredness and fatigue
- ✓Supports the nervous and immune systems
- ✓Provides nutrients essential for prenatal development
- ✓Veggie Capsule
- ✓Supports general well-being
- ✓</ul
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Ask a NaturopathFrequently Asked Questions
Everything you need to know about this product.
What is Methyl Combo?
Methyl Combo is a vegan-friendly supplement from Nature's Sunshine that delivers the already-active forms of two essential B vitamins — methylfolate (vitamin B9) and methylcobalamin (vitamin B12). By bypassing the multiple enzymatic conversions these vitamins normally require, Methyl Combo provides them in their bioavailable state so your body can put them to work right away.
What do the key ingredients in Methyl Combo do?
Methylfolate (1333 mcg DFE) and methylcobalamin (1000 mcg) work together to contribute to the methionine synthesis cycle, which produces methionine — an essential amino acid needed for healthy cell function, neurotransmitter balance, and metabolic processes. Together they support normal neurological and psychological function, may help reduce tiredness and fatigue, and provide nutrients essential for nervous system and immune system health.
How do I take Methyl Combo?
Take 1 vegcap twice daily, or as directed by your healthcare practitioner. Each bottle contains 60 capsules, providing a 30-day supply at the suggested serving.
Who is Methyl Combo best suited for?
Methyl Combo is well-suited for adults looking to support their energy levels, nervous system health, and overall well-being. It also provides nutrients considered essential for prenatal development, making it a popular choice for women who are pregnant or planning to conceive. As always, anyone who is pregnant, nursing, or taking medication should consult their healthcare practitioner before starting a new supplement.
How does Methyl Combo compare to other B-vitamin products in the range?
While Balanced B Complex, B-Complex, and Nutri-Calm offer broader B-vitamin coverage, Methyl Combo is specifically focused on delivering the active, methylated forms of B12 and folate — ideal if targeted methylation support is your priority. Liquid Methyl Vitamin B-12 Complete is another methylated option but comes in a liquid format, whereas Methyl Combo pairs B12 with methylfolate in a convenient veggie capsule. Niacin, on the other hand, focuses solely on vitamin B3, serving a different purpose altogether.
What people are saying
- Sharon Crabill9/15/2025
Methyl Combo
- Lillie Allen9/15/2025Great prices
Enjoyed the website easy to get around in the price were right on spot.
- Kimberly Soultz9/15/2025
Methyl Combo
- Caesare Smith9/15/2025Excellent Service and Products
I was raised around Nature Sunshine and know they have excellent Quality vitamins/herbs. With Caring Sunshine I like the ease of ordering and the reliability of order time.
- Jonathan Hanson9/15/2025Life changing
This has been a game changer for my health. In addition to depression and anxiety being on the curve, this is giving me energy for my day and has helped me feel so, so much better! Thank you so much!
- Marcela Jimenez9/15/2025
omega3
- Walter Kabai9/15/2025Methyl Combo
Excellent product and superb service. Thank you.
- Rolando Correa9/15/2025Great!
We are using Methyl Combo to improve our health and it is excellent. We are feeling very good.
- Tracey Mills9/15/2025Surpassed Expectations
I was a month without this vital supplement and when I resumed taking it as the doctor had ordered, my energy improved dramatically. I won't lapse again!
- AMANDA BEEGLE9/15/2025Methyl Combo
Excellent combo for methylated version of B12. It has helped me so much.
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