Pyrroloquinoline disodium salt (Pyrroloquinoline Quinone Disodium Salt (PQQ))
Synopsis of pyrroloquinoline disodium salt
Pyrroloquinoline disodium salt is the stabilized, water-soluble form of pyrroloquinoline quinone (PQQ), a redox-active compound and antioxidant found naturally in soil, certain foods (e.g., kiwifruit, fermented soy, parsley), and breast milk. PQQ functions as a redox cofactor involved in cellular energy production and is known for its role in supporting mitochondrial function, brain health, and cellular longevity. The disodium salt form enhances its solubility, stability, and bioavailability in supplements.
PQQ supports mitochondrial biogenesis—the creation of new mitochondria in cells—making it particularly valuable in conditions involving energy deficiency, aging, and cognitive decline. It also scavenges reactive oxygen species (ROS), reduces oxidative stress, and helps regulate cellular signaling pathways related to inflammation and survival.
Studies suggest PQQ may improve:
- Cognitive function, memory, and attention
- Sleep quality
- Cardiovascular health, by protecting heart tissue
- Energy levels, particularly in fatigue syndromes
It is often included in mitochondrial support formulas, nootropic stacks, and anti-aging supplements, frequently paired with Coenzyme Q10 (CoQ10) for synergistic benefits.
Historical Use in Medicine:
PQQ was first identified in 1979 as a bacterial cofactor and later found to be present in humans and higher organisms. Though not officially classified as a vitamin, PQQ exhibits vitamin-like behavior in animals and plays a role in essential cellular processes.
The disodium salt form was developed as a more stable and bioavailable version for therapeutic use and began appearing in nutraceutical products in the early 2000s, particularly in Japan and the U.S. Functional medicine practitioners adopted it for neuroprotection, mitochondrial dysfunction, and chronic fatigue, especially in patients with oxidative stress-related conditions.
Though relatively new compared to traditional herbal compounds, PQQ disodium salt is now a core ingredient in modern longevity, neuroenhancement, and energy optimization protocols, combining cutting-edge biochemical research with the principles of cellular resilience and aging support.
Pyrroloquinoline disodium salt is used for these health conditions
Alzheimer's Disease (Scientific)
Cardiovascular Disease (Scientific)
Convalescence (Scientific)
Diabetes (Scientific)
Energy (lack of) (Scientific)
Fatigue (Scientific)
Free Radical Damage (Scientific)
Inflammation (Scientific)
Memory and Brain Function (Scientific)
Stress (Scientific)
pyrroloquinoline disodium salt is used to support these body systems
Brain (Scientific)
Mitochondria (Scientific)
Nerves (Scientific)
