Trimetilglicina (TMG)

Condiciones de salud que Trimetilglicina (TMG) puede ayudar a apoyar.

• HipocondríaCientífico

  TMG contributes to antioxidant defense by generating SAMe, which is used in glutathione synthesis via transsulfuration; by reducing homocysteine-induced oxidative stress; and as an osmolyte protecting cell membranes from oxidative damage. Animal studies show betaine lowers brain and tissue MDA levels and protects cells against ROS-mediated injury. It is documented as having antioxidant and anti-inflammatory properties in peer-reviewed literature.

• Síndrome de Inmunodeficiencia AdquiridaCientífico

  TMG lowers plasma homocysteine via the BHMT pathway, and elevated homocysteine is an established biomarker of arterial damage, endothelial dysfunction, and atherosclerosis. Clinical trials consistently show TMG at 4–6 g/day reduces homocysteine by roughly 20%. However, improvements in direct measures of arterial function such as flow-mediated dilation have been inconsistent, and the lipid-raising effect at higher doses may partially offset benefit.

• Adicciones (drogas)Científico

  TMG (trimethylglycine), the chemical name for betaine, is included in the NIH ODS exercise and athletic performance fact sheet as a studied ergogenic supplement. Limited RCT evidence suggests it may enhance power output and work capacity, possibly through creatine synthesis upregulation and nitric oxide elevation.

• Fatiga SuprarrenalCientífico

  Epidemiological data and metabolomics studies link higher circulating TMG levels with lower insulin resistance and reduced type 2 diabetes risk. A randomized clinical trial in prediabetic adults showed TMG reduced insulin area under the curve during an oral glucose tolerance test, though it did not improve insulin sensitivity measured by euglycemic hyperinsulinemic clamp. Animal data is supportive but human clinical evidence remains limited and mixed.

• HisteriaCientífico

  TMG supports cellular energy through multiple routes: SAMe derived from TMG-supported methylation cycles is required for CoQ10 synthesis; TMG may enhance creatine production; it maintains mitochondrial membrane phospholipid composition; and as an osmolyte it supports cellular hydration essential for efficient energy metabolism. These are largely mechanistic links with limited dedicated human trial data for cellular energy as an isolated outcome.

• ApendicitisCientífico

  TMG exhibits anti-inflammatory properties through its role in methylation, homocysteine reduction, and AMPK pathway modulation. Preclinical evidence is strong, showing suppression of NF-κB signaling and inflammatory cytokines. Reviews of betaine supplementation in liver disease contexts document inhibition of hepatic inflammation. Robust dedicated human RCTs targeting inflammatory markers in otherwise healthy populations are limited.

• IncontinenciaCientífico

  Elevated homocysteine is consistently associated with cognitive impairment and Alzheimer's disease risk, and TMG reliably lowers homocysteine. A 24-week DB-RCT in 195 older adults found plasma betaine positively associated with construction, sensorimotor speed, and executive function at baseline; participants with the largest betaine increases showed borderline-significant memory improvement. Animal models demonstrate betaine attenuates homocysteine-induced cognitive impairment via NLRP3 inflammasome suppression.

• Trastorno por Déficit de AtenciónCientífico

  TMG augments SAMe, which is required for synthesis of serotonin, dopamine, and norepinephrine. In a RCT of 64 adults with depression, those taking SAMe plus TMG for 12 months showed greater symptom improvement than SAMe alone. A separate preliminary RCT compared SAMe plus betaine to amitriptyline, finding comparable outcomes with better tolerability. TMG has not been tested as monotherapy for depression in adequately powered human trials.

• Infección de vejigaCientífico

  Homocysteine accumulation in seminal plasma is associated with impaired sperm function; TMG's ability to reduce homocysteine provides the primary clinical rationale for its use in male fertility. A crossover RCT in healthy male athletes showed TMG at 2.5–5 g/day significantly increased total testosterone. Animal studies (roosters under heat stress) show betaine restores sperm concentration, motility, and fertility rates. Direct human sperm-quality RCT evidence remains limited.

• BronquitisCientífico

  TMG supports healthy aging primarily through homocysteine lowering and methylation support: elevated homocysteine accelerates vascular aging, cognitive decline, and oxidative burden. Circulating TMG levels decline with age and are inversely associated with multiple cardiometabolic risk factors. TMG also functions as an osmolyte protecting cells from stress, and is theorized to support mitochondrial membrane integrity and reduce age-related oxidative stress.

• JuanetesCientífico

  TMG's primary cardiac relevance is reducing homocysteine, a biomarker robustly associated with coronary artery disease and stroke risk. FDA-approved prescription betaine (Cystadane) treats homocystinuria, where uncontrolled homocysteine causes severe accelerated cardiovascular disease. For general populations, trials show homocysteine lowering but no proven reduction in hard cardiac events, and lipid-raising effects at higher doses introduce an offsetting risk.

• Depósitos de CalcioCientífico

  TMG (trimethylglycine), identical to betaine anhydrous, is the primary non-B-vitamin methyl donor for homocysteine remethylation via the BHMT enzyme in the liver. Meta-analysis of 5 RCTs confirms it reliably lowers plasma homocysteine at 4–6 g/day. It is used medically in genetic homocystinuria and is recognized in multiple authoritative nutrition references.

• Olor de piesCientífico

  Epidemiological and metabolomic studies consistently show lower plasma TMG levels are associated with insulin resistance and higher type 2 diabetes risk. A 2017 study of nearly 2,400 people linked higher betaine and choline intake with reduced insulin resistance. An RCT in prediabetic adults found betaine reduced insulin AUC after oral glucose challenge. Direct improvement of insulin sensitivity by clamp method was not demonstrated in the same trial.

• Envenenamiento QuímicoCientífico

  Trimethylglycine (betaine) is a methyl donor used in liver detoxification pathways, particularly the betaine-homocysteine methyltransferase (BHMT) reaction that remethylates homocysteine to methionine, feeding into SAMe synthesis. Clinical trials demonstrate betaine anhydrous reduces hepatic fat, ALT, AST, and histological injury in NAFLD and alcoholic liver disease patients.

• GingivitisCientífico

  TMG addresses several components of metabolic syndrome simultaneously: it lowers homocysteine, may improve insulin sensitivity, reduces hepatic lipid accumulation and inflammation, and supports methylation pathways that are commonly disrupted in metabolically unhealthy individuals. Betaine supplementation is documented to inhibit inflammation and improve insulin resistance in liver disease reviews. Evidence in specifically diagnosed metabolic syndrome patients is limited.

• Glándulas (ganglios linfáticos inflamados)Científico

  Trimethylglycine (TMG) is chemically identical to betaine and supports methylation as a direct methyl donor via BHMT, converting homocysteine to methionine independently of folate and B12. It is widely used in methylation support formulations and increasingly as a companion to NMN supplements to offset increased methylation demand from NAD+ catabolism.

• Circulación (deficiente)Científico

  TMG reduces homocysteine, which at elevated levels disrupts the mitochondrial membrane and increases mitochondrial oxidative stress. As a methyl donor, TMG also supports SAMe production, which is needed for phosphatidylcholine synthesis essential to mitochondrial membranes. Preclinical evidence shows TMG reduces mitochondrial membrane damage and MDA levels; some mechanistic data suggest it can stimulate mitochondrial biogenesis.

• Resfriados (antiviral)Científico

  TMG functions as an osmolyte, protecting muscle cells from exercise-induced stress by maintaining cellular hydration and integrity. A 2025 RCT (Nutrients, crossover, 21 cyclists, 3 g/day) found betaine supplementation reduced 60 km cycling time trial time versus placebo. Multiple trials show betaine at 2.5–3 g/day can improve strength, power output, and reduce lactate accumulation; evidence is promising but overall inconsistent across studies.

• ColitisCientífico

  TMG replenishes SAMe through the methionine cycle; SAMe is the obligate methyl donor for synthesis of serotonin, dopamine, and norepinephrine in the brain. By supporting SAMe availability, TMG indirectly sustains neurotransmitter synthesis and mood-related neurochemistry. Human studies show TMG augments SAMe's antidepressant effects, consistent with this pathway.

• Congestión (pulmones)Científico

  TMG (trimethylglycine, betaine) is an osmolyte and methyl donor that supports creatine synthesis and cellular hydration during exercise. Multiple RCTs at 2–2.5 g/day show improvements in muscle endurance, power output, and reduced fatigue. It is the same compound as betaine and has been studied specifically as an ergogenic aid for physical performance.

Sistemas corporales que Trimetilglicina (TMG) puede ayudar a apoyar.

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