Nectarine

Nectarine (Prunus persica var. nucipersica): A Comprehensive Reference

1. Identity: Botanical Classification, Nomenclature, and Natural Source

Botanical name: Nectarine (Prunus persica var. nucipersica) is a smooth-skinned mutant of peach, belonging to the family Rosaceae, sub-family Prunoideae, and genus Prunus. The species epithet persica derives from the ancient belief that the fruit originated in Persia, though this was later refuted. Additional accepted botanical synonyms applied in the literature include Prunus persica (L.) Batsch var. nectarina (Ait.) Maxim and, in some classifications, Prunus persica L. Batsch var. nucipersica. Peaches (Prunus persica L. Batsch) and nectarines (Prunus persica L. Batsch var. nectarina [Ait] Maxim) are the third-most economically important fruit tree crops after apples (Malus spp.) and pears (Pyrus spp.).

Genetic distinction from peach: A genetic variant of common peaches, the nectarine was most likely domesticated in China more than 4,000 years ago. The expression of a recessive allele is thought to be responsible for the smooth skin of nectarine fruits, which lack the fuzzy trichomes (plant hairs) characteristic of peach fruits. Peaches and nectarines are the same species; the difference between them comes down to a single gene — the MYB25.

Common forms and preparations: Nectarines are a source of vitamins A and C and are commonly eaten fresh or cooked in conserves, jams, and pies. From a dietary supplement perspective, nectarine is utilized in several processed forms: the nutritional composition and antioxidant potential of industrial by-products derived from various cultivars of nectarines (Prunus persica var. nucipersica), specifically peels, kernels, and pulps, have been studied to evaluate their suitability as functional food ingredients. A notable supplemental form involves thinned nectarines — immature fruits removed during orchard crop-thinning operations — which are processed into nutraceutical formulations rich in abscisic acid and polyphenolic extracts.

Cultivar diversity: Peaches and nectarines have the highest number of new cultivars released every year by intensive breeding programs worldwide. Nectarines have red, yellow, or white pulp, with most varieties bearing an attractive red colour of varying shades. Fruit shape also varies considerably from beaked and round-to-flat. Among the most popular varieties of nectarines are Nectagala, Nectatinto, and Luciana, all recognized for their early ripening, high sugar–acid balance, and suitability for multiple applications within the fresh and processed fruit market.

2. Historical and Traditional Use

2.1 Origins in Ancient China

The history of the nectarine is inseparable from that of the peach, with which it shares its species designation. The cultivated/domesticated peach (Prunus persica var. persica; Rosaceae, subgenus Amygdalus; synonym: Amygdalus persica) originated in China. Five populations of archaeological peach stones recovered from Zhejiang Province, China, document peach use and evolution beginning ca. 8000 BP. The oldest archaeological peach stones are from the Kuahuqiao (8000–7000 BP) and Tianluoshan (7000–6500 BP) sites, and both stone samples segregate into two size groups, suggesting early selection of preferred types.

Peaches were cultivated in China as early as 2000 BCE, but archaeologists have unearthed peach stones that date back more than 7,500 years to the Zhejiang province of China. Peaches appear in ancient Chinese texts dating to the tenth century BCE. Peach has been an important aspect of traditional culture in China, and was considered a symbol of immortality in Daoist mythology. The peach symbolizes immortality in Chinese Taoist mythology and is referenced in the legend of Xiwangmu, the Queen Mother of the West, a goddess who lived in a jade palace surrounded by peach trees bearing fruits of immortality.

As members of the same species, nectarines (Prunus persica var. nucipersica, or var. nectarina) can be clingstone or freestone, but the main difference between them and other types of peaches is their silky, smooth skin, free of fuzz. With firm pulp and a honey-like, sweet flavour, nectarines are very popular for cooking.

2.2 Spread Along the Silk Road and into Europe

Originating from China over 4000 years ago, peaches were introduced to Persia through the Silk Road during the Han Dynasty and gradually spread to India, Greece, Rome, Egypt, Europe, and America. By 50 to 20 B.C.E., Romans grew peaches and spread them to the north and west of the European empire. They called the peach a "Persian apple," and the name for peach in numerous languages derived from that. The Spaniards brought peaches to South America and the French introduced them to Louisiana. Columbus brought trees to America on his 2nd and 3rd voyages.

2.3 Traditional Medical Use in East Asia

Within Traditional Chinese Medicine (TCM), the peach and its close variant the nectarine have been used therapeutically for centuries. The Chinese medical texts cite that peaches enter the channels of the Stomach, Liver, and Small Intestine. Peach fruit is enjoyed in the West, but in China the pits are also used as an important medicine for treating conditions caused by blood stagnation. In China, peaches are associated with longevity and vitality. The name "nectarine" itself has ancient linguistic roots: the name is believed to be derived from the word "nectar," referring to the sweet liquid produced by flowers, which is often associated with the divine beverages served to the gods in Greek mythology.

3. Key Constituents and Active Compounds

3.1 Polyphenolic Profile

Nectarine (Prunus persica) is a fruit belonging to the Rosaceae family, rich in hydroxycinnamates, procyanidins, flavonols, anthocyanins, vitamin C, β-carotenoids, and polyphenols. The polyphenolic profile varies significantly by cultivar and flesh color. Hydroxycinnamic acids, which are part of the phenolic acids, are predominantly present in white nectarine, representing 70.70% of the total polyphenols identified. Next come flavanols, which are part of the flavonoids (11.40% of total polyphenols). Flavonols and anthocyanins, belonging to the flavonoid family, account for 9.50% and 8.50% of total polyphenols respectively.

Nectarine genotypes chiefly contain phloridizin dihydrate and chlorogenic acid as the phenolic component. Neochlorogenic acid content is higher in nectarines than in peaches. Quantitative ranges of total phenolics measured across California-grown cultivars demonstrate the considerable inter-cultivar variability: genotypic variation in composition and antioxidant activity was evaluated using 25 cultivars — 5 each of white-flesh nectarines, yellow-flesh nectarines, white-flesh peaches, yellow-flesh peaches, and plums — at the ripe stage. Total ascorbic acid (vitamin C) ranged from 5–14 mg/100 g (white-flesh nectarines) and 6–8 mg/100 g (yellow-flesh nectarines). Total carotenoids were 7–14 μg/100 g (white-flesh nectarines) and 80–186 μg/100 g (yellow-flesh nectarines). Total phenolics were 14–102 mg/100 g (white-flesh nectarines) and 18–54 mg/100 g (yellow-flesh nectarines).

The phytochemical profile of the fruit varies according to the cultivar. The composition of flavonoids and anthocyanins increases during fruit growth and ripening. The methanolic extract of the peel appears to be richer in the studied biologically active substances compared to the fleshy part of the fruit.

3.2 Carotenoids

Nectarines contain a fairly good amount of antioxidant vitamins such as C, A, and E, and flavonoid polyphenolic antioxidants like lutein, zeaxanthin, and β-cryptoxanthin. The content of beta-carotene (provitamin A) depends on the color of the cultivar (white, yellow, orange-yellow, red). Nectarines, along with oranges, tangerines, mango, and papaya, are rich in cryptoxanthin. Dietary sources of zeaxanthin are limited to greens and certain yellow/orange fruits and vegetables such as corn, nectarines, oranges, papaya, and squash. Yellow-flesh nectarines contain substantially more total carotenoids than their white-flesh counterparts, as indicated by the ranges reported above.

3.3 Sugars and Organic Acids

Sucrose is the main sugar detected in nectarine fruits, with a percentage content of 78.29% and 78.12% of total sugar content in yellow and white nectarines, respectively. Sugar is composed on average from 13% glucose, 15% fructose, and 72% sucrose. Organic acids fluctuate according to degree of ripeness, with approximately 42% citric acid and 58% malic acid.

3.4 Vitamins and Minerals

Nutritionally, nectarines are on par with peaches. Fresh nectarines provide twice the vitamin A, slightly more vitamin C, and much more potassium and fibre than peaches, and possess strong flavour and aroma. The content of dietary fibre and mineral salts, principally potassium, is important. The vitamins best represented in white nectarines are vitamins E and B9, with vitamin E at 1.04 mg per 100 g (8.67% of Dietary Reference Values) and B9 at 11.90 μg per 100 g (5.95% of DRVs).

3.5 Abscisic Acid (ABA)

A phytohormone of particular interest in the nutraceutical context is abscisic acid (ABA). A screening of different fruit thinning by-products identified thinned nectarines (TN) as the richest matrices of abscisic acid (ABA), a phytohormone with well-documented hypoglycemic potential. ABA is a naturally occurring plant hormone found at the immature stage in various fruits, including nectarines. Several studies have also demonstrated a role for ABA as an endogenous hormone exhibiting antidiabetic properties in humans by enhancing glucose uptake and improving insulin sensitivity.

3.6 Polyphenol Profiles in Thinned Nectarines

HPLC analyses of thinned nectarine nutraceutical formulations have allowed identification of forty-eight polyphenolic compounds, nineteen of which were quantified. Thinned nectarines have been shown to contain high levels of polyphenols compared to their mature counterparts.

4. Mechanisms of Action

4.1 Antioxidant Activity

The primary mechanism of action attributed to nectarine constituents across multiple research lines is antioxidant activity mediated through its complex polyphenolic mixture. Bioactive compounds within fruits are the main reason for the increased benefits of consuming them. There has been growing interest in bioactive substances because of their antioxidant potential and the association between their consumption and the prevention of some diseases. Peaches and nectarines are a rich source of bioactives including ascorbic acid (vitamin C), carotenoids (provitamin A), and phenolic compounds.

Chlorogenic acid (CGA), a principal polyphenol in nectarines, exerts antioxidant effects through a specific molecular pathway: CGA's antioxidant effects, mediated through the Nrf2-heme oxygenase-1 signaling pathway, have been shown to enhance the levels of antioxidant enzymes such as superoxide dismutase, catalase, glutathione-S-transferases, glutathione peroxidase, and glutathione reductase, as well as glutathione content.

4.2 Anti-inflammatory Mechanisms

Chlorogenic acid could suppress inflammation via inhibition of toll-like receptor 4 and MyD88, and the phosphorylation of inhibitor of kappa B and p65 subunit of NF-κB, resulting in diminished levels of downstream inflammatory factors including interleukin (IL)-1β, IL-6, tumour necrosis factor-α, macrophage inflammatory protein 2, cyclooxygenase-2, and prostaglandin E2.

4.3 Metabolic and Hypoglycemic Mechanisms

Chlorogenic acid possesses many health-promoting properties, most of them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive activities. In terms of glucose metabolism, polyphenols present in nectarines have demonstrated potential in diabetes control. These molecules exert antioxidant and anti-inflammatory properties that can help regulate glycemic levels and improve insulin resistance.

4.4 Carotenoid Mechanisms: Ocular and Dermal Protection

β-carotene is a precursor of vitamin A that essentially functions in many biological processes including vision. The human macula lutea and eye lens are rich in lutein, zeaxanthin, and meso-zeaxanthin, collectively known as macular xanthophylls, which help maintain eye health and prevent ophthalmic diseases. Ocular carotenoids absorb light from the visible region (400–500 nm wavelength), enabling them to protect the retina and lens from potential photochemical damage induced by light exposure.

5. Scientific Evidence by Area of Use

5.1 Longevity and Aging: Preclinical Model Evidence

The most cited preclinical study investigating nectarine's direct biological effects on aging was conducted at the National Institute on Aging and published in Free Radical Biology and Medicine (2011). Researchers investigated the effects of nectarine, a globally consumed fruit, on lifespan and healthspan in Drosophila melanogaster. Wild-type flies were fed standard, dietary restriction, or high-fat diet supplemented with 0–4% nectarine extract. Researchers measured lifespan, food intake, locomotor activity, fecundity, gene expression changes, and oxidative damage indicated by the level of 4-hydroxynonenal-protein adduct in these flies. The mean lifespan of female flies increased by 14–22% when fed with 4% nectarine extract, with no such effect on male flies. This study was a preclinical animal model experiment; it provides no direct evidence of longevity effects in humans and must be interpreted accordingly.

5.2 Glucose Metabolism and Antidiabetic Effects

The most clinically relevant evidence specific to nectarine as a supplement concerns its use as a source of abscisic acid (ABA) in thinned nectarine formulations. The beneficial efficacy of a nutraceutical formulation based on thinned nectarines (TNs) rich in ABA was tested through a three-month, three-arm, parallel-group, randomized controlled trial (RCT) conducted on sixty-one patients with type 2 diabetes (T2D). After 3 months, both the treatments with low doses of TN (500 mg 3 times/day) and high doses of TN (750 mg 3 times/day) showed a significant reduction in glycemic parameters compared to baseline. Treatment with low doses of TN showed a greater insulin-sparing effect (fasting plasma insulin: −29.2%, p < 0.05).

An earlier study by the same research group provided mechanistic grounding: a novel nutraceutical formulation based on thinned nectarine polyphenolic extract was chosen as an ideal candidate and tested for hypoglycemic potential. The results showed the ability of this formulation to positively influence postprandial glycemia in healthy human subjects in association with an insulin-sparing mechanism of action.

In vitro cell-line research extended this work: thinned nectarines have gained increasing interest due to their high polyphenol and abscisic acid (ABA) content, both of which possess antidiabetic properties. Nevertheless, the efficacy of these bioactive compounds may be compromised by limited stability and bioavailability in vivo. The study aimed to develop nanoformulations (NFs) containing pure ABA or a TN extract (TNE) at an equivalent ABA concentration. NF-TNE treatment exhibited enhanced antioxidant activity compared to free TNE, while ABA-based groups showed no significant antioxidant activity.

The investigators themselves state clearly: the concomitant presence of different bioactive compounds in the TN-based nutraceutical formulation, such as ABA and polyphenols, would reasonably support TN as an innovative nutraceutical formulation useful for the management of glucose homeostasis. Further in-depth animal-based studies and clinical trials are needed to deepen these aspects.

5.3 Chlorogenic Acid: Metabolic Syndrome and Antidiabetic Effects (Ingredient-Level Evidence)

Because chlorogenic acid is a primary nectarine constituent, its clinical profile is relevant to understanding nectarine's pharmacological potential, with the caveat that CGA studies use concentrated isolated forms not equivalent to whole fruit consumption. In a cohort of 15 patients with impaired glucose tolerance (IGT), CGA (400 mg three times per day for 3 months) decreased fasting serum glucose, insulinogenic index, body weight, body mass, waist circumference, triglycerides, total cholesterol, LDL-c, and very low-density lipoprotein levels, with an upregulated Matsuda index.

Human studies have also revealed anti-obesity effects of chlorogenic acid-rich foods. Thom gave 30 overweight subjects for 12 weeks either five cups of normal instant coffee per day or five cups of Coffee Slender® per day (rich in chlorogenic acid and its isomers, ~45 mg/g). Participants showed a significant reduction in weight (p < 0.05; −5.4 kg) with Coffee Slender®, where 80% of the reduction was due to loss of body fat. Participants who drank normal instant coffee showed non-significant reductions in body weight and body fat. These findings are specific to coffee-sourced CGA-rich preparations and are not directly generalizable to whole nectarine consumption.

5.4 Antioxidant and Oxidative Stress Biomarkers: Acute Human Evidence

In a randomized crossover study, healthy postmenopausal women (BMI 25–40, n = 16) who consumed a bioactive yogurt containing curcumin and CGA showed significantly lower plasma levels of TNFα compared to the placebo group and the baseline. In an acute pilot study, healthy subjects (n = 31) were given a single dose of a polyphenol-rich beverage or placebo. Plasma levels of 8-iso-PGF2-alpha and advanced oxidation protein products were decreased, and hydroxyl radical antioxidant capacity at one-hour post-intake was increased compared to baseline. These studies involve multi-component polyphenol preparations, not nectarine in isolation.

5.5 Cardiovascular Health: Polyphenol-Level Evidence

No clinical trial has tested nectarine specifically for cardiovascular outcomes. The available evidence operates at the level of dietary polyphenols generally. Evidence on beneficial effects of polyphenols is mainly derived from in vitro or animal experiments, as well as some human epidemiological studies. Epidemiological studies tend to accept a protective role of polyphenol-containing foods on cardiovascular disease. This body of evidence is supportive but not conclusive, and does not specifically implicate nectarine fruit or nectarine-derived supplements.

5.6 Gut Microbiome Modulation

Despite growing evidence of polyphenols' health-promoting effects, their mechanisms remain poorly understood due to high interindividual variability in bioavailability and metabolism. Recent research highlights the bidirectional relationship between dietary polyphenols and the gut microbiota, which can influence polyphenol metabolism and, conversely, be modulated by polyphenol intake. Nectarine is included among polyphenol food sources in systematic reviews investigating gut microbiota modulation, alongside other polyphenol-containing foods such as tea, soy, red wine, apple, grape, berry, cherry, orange, plum, and others. No trials have isolated nectarine's specific contribution to human microbiome modulation.

5.7 Ocular Health

Nectarine's carotenoids — particularly zeaxanthin and lutein — are dietary sources of macular pigment precursors. Among the more than 750 carotenoids identified in nature, only lutein, zeaxanthin, meso-zeaxanthin, and their oxidative metabolites are selectively accumulated in the macula lutea region of the human retina. These retinal carotenoids are obtained only through dietary sources such as green leafy vegetables and yellow and orange fruits and vegetables. Dietary sources of zeaxanthin include certain yellow/orange fruits and vegetables such as corn, nectarines, oranges, papaya, and squash. However, no clinical study has examined nectarine consumption specifically in relation to macular health outcomes; the evidence here is indirect and extrapolated from carotenoid research.

5.8 Cancer: Preliminary and Indirect Evidence

Preventive effects of polyphenols on chronic diseases such as cancer are generally considered preliminary. In addition to associations between polyphenols and cancer risks, factors such as host genetic susceptibility, epigenetic modification, and gut microbiome patterns may also impact on the protective roles of polyphenols. More evidence should be collected by utilizing biomarkers of exposure for polyphenols in future epidemiological studies before a clear conclusion can be made. No clinical evidence specifically implicating nectarine — as a food or supplement — in cancer prevention has been identified in peer-reviewed literature.

6. Body Systems and Health Areas of Association

• Endocrine / Metabolic system: The most clinically substantiated area. ABA from thinned nectarines has been directly tested in an RCT for glycaemic control in type 2 diabetics. CGA (a primary constituent) has metabolic syndrome activity supported by small human trials.
• Cardiovascular system: Polyphenolic constituents (chlorogenic acid, procyanidins, flavonols) are associated with endothelial and lipid-related effects in preclinical and epidemiological data. No nectarine-specific cardiovascular human trials exist.
• Gastrointestinal / Microbiome: Nectarine's polyphenols are substrates for gut microbial metabolism. Dietary fibre contributes to digestive health. Evidence is indirect and extrapolated from broader polyphenol research.
• Visual system: Zeaxanthin and lutein from nectarines are dietary sources of macular pigment carotenoids, associated with protection against age-related macular degeneration in epidemiological and clinical studies of these isolated nutrients.
• Integumentary / Skin: Carotenoids protect skin against oxidation induced by sunlight exposure. Lutein and zeaxanthin have been reported to reduce lipid peroxidation and increase moisture in the skin. The anti-oxidative effect of lutein also protects against UV-induced skin damage. Nectarine's β-cryptoxanthin and carotenoids are relevant here.
• Oxidative stress / Cellular defence: Multiple constituents (chlorogenic acid, vitamin C, carotenoids) engage Nrf2 and antioxidant enzyme pathways, supported by in vitro and some human biomarker studies.
• Immune and inflammatory pathways: CGA inhibits NF-κB and pro-inflammatory cytokine signalling in preclinical models; limited human data available.

7. Dosage Forms and Dosages Reported in Studies

The following dosages appear specifically in the cited studies and are reported here as documented — they do not represent recommended intake levels.

• Thinned nectarine nutraceutical formulation (oral capsule), T2D RCT: Both low-dose TN (500 mg three times per day) and high-dose TN (750 mg three times per day) were administered for 3 months in a randomized controlled trial on sixty-one patients with type 2 diabetes.
• Nectarine extract in Drosophila lifespan study: Wild-type flies were fed standard, dietary restriction, or high-fat diet supplemented with 0–4% nectarine extract. This is a preclinical preparation with no direct human equivalent dose.
• Chlorogenic acid (isolated constituent), impaired glucose tolerance cohort: CGA was administered at 400 mg three times per day for 3 months.
• Whole fruit (nutritional reference): Nectarines have a low calorific value (44 calories/100 g pulp). The white nectarine, with skin, brings on average 51.80 kcal per 100 g.

8. Safety Considerations and Known Interactions

8.1 Allergenic Proteins and Allergy Phenotypes

Allergy to peaches (Prunus persica) and nectarines is one of the most common food allergies. In Mediterranean countries, Prunus persica is the most common trigger of plant food allergies. Two distinct allergic phenotypes are well-characterised in the scientific literature:

• Lipid Transfer Protein (LTP) sensitization (Pru p 3): Peach allergy sufferers are more than 80% sensitized by the lipid transfer protein Pru p 3. The sensitization is primarily gastrointestinal, probably through consumption of ripe peaches. Pru p 3 is a heat- and acid-stable lipid transfer protein. Pru p 3 can be detected in the skin area at seven times higher activity than in the fruit flesh. Therefore, allergy sufferers can often eat peeled fruits without allergic reactions. Due to its high IgE reactivity and cross-reactive properties, Pru p 3 is considered a biomarker for a general sensitization against members of the lipid transfer protein family. However, about 50% of the sensitizations are biologically not relevant.
• Birch pollen cross-reactivity (Oral Allergy Syndrome / Pollen-Food Syndrome): Like many other allergies to fresh fruits and vegetables, peach allergy can take two different forms. In northern Europe, people with birch-pollen allergy can develop a peach allergy due to the similarity between a birch protein and a peach protein. This is called the birch-fruit syndrome with symptoms generally appearing within 5–15 min after consuming raw peach and comprising local reactions in the mouth and throat (oral allergy syndrome, OAS). The molecule involved in this kind of allergy does not survive cooking. Therefore, people who react to this allergen can tolerate cooked peach and juices.

30–50% of birch pollen allergic individuals show allergic reactions after consuming peaches, a prevalence that is only exceeded by allergic reactions to apples and hazelnuts.

8.2 Cross-Reactivity Across Stone Fruits

Clinical cross-reactivity to Prunoideae is essentially due to a common 13 kDa IgE-binding component, which appears to be the most important major allergen of this subfamily, not shared with grass and birch pollen. Having a negative reaction to nectarines, peaches, or stone fruits generally corresponds with a birch pollen allergy. Nectarines share allergen epitopes with peaches, apricots, plums, and cherries.

8.3 Bioavailability Limitations of Nectarine-Derived Bioactives

Thinned nectarines have gained increasing interest due to their high polyphenol and abscisic acid (ABA) content, both of which possess antidiabetic properties. Nevertheless, the efficacy of these bioactive compounds may be compromised by limited stability and bioavailability in vivo. This concern has motivated the development of nanoformulation delivery systems for thinned nectarine extracts.

8.4 Variability of Phytochemical Content

The values for polyphenol and nutrient composition are approximate and depend on variety, season, ripeness, and cultivation conditions. Variability is found among cultivars for the chemical compounds analysed. This means that the bioactive content of nectarine-based preparations can differ substantially between sources and products.

8.5 Absence of Established Drug Interaction Data

No published clinical studies in the peer-reviewed literature identified in this review document specific pharmacokinetic drug interactions attributable to nectarine fruit or nectarine-derived supplements. The phenolic constituents (particularly chlorogenic acid) have mechanistic potential to influence glucose metabolism and thus could be pharmacodynamically relevant in individuals taking hypoglycemic medications, but this has not been quantitatively characterised in human interaction studies. The ABA-rich thinned nectarine RCT measured insulin-sparing effects in diabetic patients, which implies a need for monitoring in this population.

References

• Bhardwaj R et al. Chemical and nutritional evaluation of major genotypes of nectarine (Prunus persica var nectarina) grown in North-Western Himalayas. Biological Agriculture & Horticulture, 2019. PMC6706499
• Nectarine — ScienceDirect Topics Overview (Chemical composition of peaches and nectarines)
• Gil MI et al. Antioxidant Capacities, Phenolic Compounds, Carotenoids, and Vitamin C Contents of Nectarine, Peach, and Plum Cultivars from California. Journal of Agricultural and Food Chemistry, 2002.
• Milkovska-Stamenova S et al. Comparative Study of Early- and Mid-Ripening Peach (Prunus persica L.) Varieties: Biological Activity, Macro-, and Micro-Nutrient Profile. Foods, 2021. PMC7830338
• Medrano-Padial C et al. Evaluation of the Fruit Quality and Phytochemical Compounds in Peach and Nectarine Cultivars. Plants, 2023. PMC10144225
• Zheng Y, Crawford GW, Chen X. Archaeological Evidence for Peach (Prunus persica) Cultivation and Domestication in China. PLOS ONE, 2014. PMC4156326
• Britannica: Nectarine (Prunus persica) — Description, Cultivation, and Nutrition
• Rashad A et al. Origins and Genetic Characteristics of Egyptian Peach. Horticulturae, 2024. PMC11313342
• Aprifel — White Nectarine: Calories and Nutritional Composition (European Fresh Produce Association)
• Boyd O et al. Nectarine Promotes Longevity in Drosophila melanogaster. Free Radical Biology and Medicine, 2011. PMC3090488
• Boyd O et al. Nectarine promotes longevity in Drosophila melanogaster. PubMed PMID: 21406223
• Putignano P et al. Thinned Nectarines, an Agro-Food Waste with Antidiabetic Potential: HPLC-HESI-MS/MS Phenolic Characterization and In Vitro Evaluation of Their Beneficial Activities. Foods, 2022. PMC8997825
• Lisco G et al. Beneficial Contribution to Glucose Homeostasis by an Agro-Food Waste Product Rich in Abscisic Acid: Results from a Randomized Controlled Trial. Frontiers in Endocrinology, 2022. PMC9455828
• Putignano P et al. Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line. Antioxidants, 2024. PMC10812739
• Naveed M et al. Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome. Journal of Functional Foods, 2018. PMC6155416
• El-Saber Batiha G et al. A review of the protective effects of chlorogenic acid against different chemicals. Drug and Chemical Toxicology, 2023. PubMed PMID: 35609009
• Sato Y et al. Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials. Antioxidants, 2024. PMC11013850
• Wang Y et al. Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism. Toxicology Letters, 2013. PubMed PMID: 24011717
• Johra FT et al. A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease. Antioxidants, 2020. PMC7692753
• Mozaffarieh M et al. The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration. Nutrition Journal, 2003. PMC305368
• Kowalska M et al. Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough? Antioxidants, 2019. PMC6719967
• Sasaki M et al. Effect of an antioxidant supplement containing high dose lutein and zeaxanthin on macular pigment and skin carotenoid levels. Scientific Reports, 2020. PMC7314813
• Zamora-Ros R et al. Biomarkers of Dietary Polyphenols in Cancer Studies: Current Evidence and Beyond. Oxidative Medicine and Cellular Longevity, 2015. PMC4477246
• Selma MV et al. Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies. Nutrients, 2024. PMC11673714
• Altmeyer P. Peach Allergy — Altmeyer's Encyclopedia, Allergology
• Manzotti G et al. Phenotypes and Endotypes of Peach Allergy: What Is New? Foods, 2022. PMC8912752
• Pastorello EA et al. The major allergen of peach (Prunus persica) is a lipid transfer protein. Journal of Allergy and Clinical Immunology, 1999. PubMed PMID: 10069889
• Pastorello EA et al. Allergenic cross-reactivity among peach, apricot, plum, and cherry in patients with oral allergy syndrome. Journal of Allergy and Clinical Immunology, 1994. PubMed PMID: 7930303
• Drobek M et al. Comparative study of nutrient and antioxidant contents in by-products of peach and nectarine varieties. Discover Food, 2025.