Alpha-glycosyl isoquercitrin
Synopsis of alpha-glycosyl isoquercitrin
Alpha-glycosyl isoquercitrin (AGIQ) is a water-soluble flavonoid compound derived from isoquercitrin, itself a glycoside form of quercetin, one of the most well-researched antioxidant flavonoids in the plant kingdom. AGIQ is created through a natural enzymatic process that attaches alpha-glucose chains to isoquercitrin, enhancing its solubility, bioavailability, and absorption in the human body. This makes AGIQ a superior delivery form of quercetin, especially for use in dietary supplements and functional food products.
AGIQ retains the powerful antioxidant, anti-inflammatory, and antihistamine properties of quercetin, while being more easily absorbed and utilized. It scavenges free radicals, supports immune modulation, and stabilizes mast cells, making it particularly effective in allergy relief, inflammatory conditions, and oxidative stress-related disorders. Studies also show AGIQ may help reduce histamine release, lower cytokine activity, and protect tissues against cellular damage, making it useful in supporting respiratory health, cardiovascular function, and joint integrity.
Due to its enhanced bioavailability compared to quercetin aglycone or isoquercitrin alone, AGIQ is often used in sports nutrition, eye health, and immune support formulations. It has been studied for its neuroprotective potential, its ability to reduce exercise-induced oxidative damage, and for assisting in recovery from seasonal allergies or inflammatory stress.
AGIQ is recognized as Generally Recognized as Safe (GRAS) and is often included in functional beverages, gummies, powders, and capsules, especially where rapid or efficient absorption is desired.
Historical Use:
Alpha-glycosyl isoquercitrin itself is a modern, bio-enhanced derivative developed through advancements in flavonoid chemistry and enzymology in the late 20th and early 21st centuries. It does not appear in any traditional medical systems or historical pharmacopeias in its current form.
However, its parent compounds—quercetin and isoquercitrin—are widely found in traditional medicinal plants, including onion, apple peel, elderflower, St. John’s wort, and Japanese pagoda tree (Sophora japonica). These plants have long been used in herbal medicine to treat inflammation, allergies, infections, and circulatory issues. For example, Sophora japonica, one of the richest natural sources of isoquercitrin, has been used in Traditional Chinese Medicine to cool the blood, stop bleeding, and relieve hemorrhoids.
While ancient practitioners did not isolate flavonoids like AGIQ, they recognized the health-promoting effects of quercetin-rich herbs, often using them to reduce heat, swelling, and allergic reactions—functions consistent with the known activity of AGIQ today.
Thus, alpha-glycosyl isoquercitrin represents a modern refinement of traditional herbal compounds, combining centuries-old botanical wisdom with contemporary biochemical innovation to create a highly absorbable, well-tolerated antioxidant for inflammation, allergy support, and whole-body protection.
Alpha-glycosyl isoquercitrin is used for these health conditions
Aging (prevention) (Scientific)
Allergies (respiratory) (Scientific)
Chemotherapy (reducing side effects) (Scientific)
Diabetes (Scientific)
Diabetic Retinopathy (Scientific)
Fatty Liver Disease (Scientific)
Free Radical Damage (Scientific)
Inflammation (Scientific)
Inflammatory Bowel Disorders (Scientific)
Metabolic Syndrome (Scientific)
alpha-glycosyl isoquercitrin is used to support these body systems
Capillaries (Scientific)
Circulatory System (Scientific)
Immune System (Scientific)
Skin (Scientific)
