NatureWise Triple Magnesium Complex | Caring Sunshine

If you've been researching Magnesium supplements, you've likely come across the naturewise triple Magnesium Complex concept — combining multiple highly bioavailable forms of Magnesium into a single capsule for broader support. This Nature's Sunshine Magnesium Complex delivers exactly that principle, pairing Magnesium citrate and Magnesium malate in a highly soluble formula designed to support the heart, brain, kidneys, and bones.

Magnesium is the fourth most abundant cation in the human body and a critical cofactor in more than 300 enzyme systems. It regulates energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and immune defense. Despite its importance, emerging evidence confirms that nearly two-thirds of the population in the Western world is not achieving the recommended daily allowance for Magnesium — a widespread shortfall that may contribute to various health conditions.

This naturewise triple Magnesium Complex approach uses organic forms of the mineral — citrate and malate — which are generally more soluble and have higher bioavailability than inorganic forms such as Magnesium oxide. Research has shown that Magnesium citrate, for example, had high solubility even in water (55%) and was substantially more soluble than Magnesium oxide in all states of acid secretion. Two capsules of this Magnesium Complex provide 184 mg of Magnesium.

If you have questions about whether a Magnesium Complex fits your health goals, our naturopath is available for a free consultation — no appointment pressure, just practical guidance.

Not all Magnesium supplements are created equal. Organic forms such as Magnesium citrate and Magnesium malate involve Magnesium chelated to organic acid molecules, which makes them generally more soluble and better absorbed than inorganic alternatives. By combining two organic forms, this naturewise triple Magnesium Complex formula offers complementary pathways of absorption and a broad foundation of support.

Cardiovascular Support

Research suggests that Magnesium plays a well-documented role in cardiovascular health. Higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across multiple large meta-analyses and prospective cohort studies. Magnesium regulates cardiac ion channels, myocardial conduction, and vascular tone. In a 24-week randomized controlled trial, 350 mg/day of Magnesium citrate significantly reduced arterial stiffness as measured by pulse wave velocity, and Magnesium also participates in vascular calcification prevention and improves flow-mediated dilation.

In 2022, the U.S. FDA approved a qualified health claim stating that consuming diets with adequate Magnesium may reduce the risk of high blood pressure, though the agency noted the evidence is inconsistent and inconclusive. Multiple RCTs and meta-analyses have found modest but significant reductions in blood pressure, particularly in Magnesium-deficient or hypertensive individuals.

Nervous System Support

Magnesium is fundamental to nervous system function, acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability, neuromuscular transmission, and nerve signaling. It plays a critical role in nerve excitability by blocking NMDA receptors and regulating calcium and potassium channels. Deficiency is clinically associated with neuromuscular hyperexcitability, tremors, and even seizures.

Studies also suggest Magnesium is an essential cofactor in dopamine synthesis and a physiological blocker of NMDA glutamate receptor channels, supporting inhibitory-excitatory neurotransmitter balance. A 2017 RCT showed that 248 mg/day of Magnesium significantly reduced both depression and anxiety scores.

Bone Density Support

Magnesium is the second most abundant mineral in bone and is essential for vitamin D activation and calcium metabolism. It influences the activities of osteoblasts and osteoclasts — the cells that build and remodel bone tissue — and affects concentrations of parathyroid hormone. Observational data from large cohort studies found that higher Magnesium intake is associated with 2–3% greater bone density in women. One short-term study found that 290 mg/day of elemental Magnesium as Magnesium citrate for 30 days in postmenopausal women with osteoporosis suppressed bone turnover compared with placebo.

Because Magnesium is involved in so many body systems, a wide range of people may benefit from supplementation — especially given how common dietary shortfalls are. It is estimated that between 56 and 68% of Americans do not obtain enough Magnesium in their diet on a daily basis to meet the recommended daily allowance.

Older adults are particularly susceptible to Magnesium deficiency due to decreased absorption from food, increased medication use (certain diuretics can deplete Magnesium), and potential dietary restrictions. As we age, Magnesium absorption and retention can decrease, leading to deficiency and health consequences.

People concerned about heart health may appreciate that research consistently associates higher Magnesium levels with lower risks of arrhythmia, hypertension, coronary artery disease, and heart failure. Magnesium is a well-established cofactor in cardiac electrophysiology, modulating ion channel exchanges and action potentials.

Those focused on bone health — particularly postmenopausal women — may value the research showing that low Magnesium is associated with increased osteoporosis risk and that supplementation may protect bone density. A systematic review and meta-analysis found that higher Magnesium intake is associated with increased hip and femoral neck bone mineral density in older adults.

Anyone taking certain medications should be aware that loop and thiazide diuretics, proton pump inhibitors (PPIs) used for more than a year, and other common drugs can deplete Magnesium. If you take any of these, our naturopath can help you evaluate whether a Magnesium Complex makes sense for your routine — just reach out for a free consultation.

Take 2 capsules twice daily with a meal. Each bottle contains 100 capsules. Taking Magnesium with food supports absorption and helps minimize the mild digestive effects that some people experience with supplemental Magnesium.

The Recommended Dietary Allowance for Magnesium is 400–420 mg/day for adult men and 310–320 mg/day for adult women. Because Magnesium supplements can interact with certain medications — including bisphosphonates, tetracycline and quinolone antibiotics, diuretics, proton pump inhibitors, and gabapentin — it's important to separate doses appropriately. For instance, Magnesium and oral bisphosphonates should be separated by at least 2 hours, and antibiotics should be taken at least 2 hours before or 4–6 hours after Magnesium.

If you're unsure about timing around your current medications, our naturopath can walk you through it during a free consultation.