Magnesium Complex Supplement | Heart, Brain & Kidney

A Magnesium Complex supplement combines more than one form of Magnesium in a single capsule so your body can take advantage of each form's unique absorption profile. Nature's Sunshine Magnesium Complex pairs Magnesium citrate and Magnesium malate — two organic, highly soluble forms — to support the brain, heart, and kidneys with this essential mineral.

Magnesium is the fourth most abundant cation in the human body and serves as a cofactor in more than 300 enzyme systems that regulate energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and more. Despite its importance, an estimated 56–68% of Americans do not obtain enough Magnesium from their diet to meet the recommended daily allowance.

Because organic Magnesium forms such as citrate and malate are generally more soluble and have higher bioavailability than inorganic forms like Magnesium oxide, a Magnesium Complex supplement built around these two forms is designed for optimum effectiveness. Magnesium citrate, for example, has been shown to have high solubility even in water (55%) and is substantially more soluble than Magnesium oxide in all states of acid secretion.

Cardiovascular System

Research suggests that Magnesium plays a well-documented role in cardiovascular health. Higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across multiple large meta-analyses and prospective cohort studies. Magnesium regulates cardiac ion channels, myocardial conduction, and contraction, and hypomagnesemia is directly linked to arrhythmias and increased cardiovascular risk.

Studies also suggest Magnesium supplementation may modestly but significantly reduce blood pressure, particularly in Magnesium-deficient or hypertensive individuals. A 2021 systematic review of 49 clinical trials confirmed these antihypertensive effects, with mechanisms including vasodilation, calcium channel antagonism, and RAAS modulation. In 2022, the FDA approved a qualified health claim stating that consuming diets with adequate Magnesium may reduce the risk of high blood pressure, though the agency characterized the evidence as inconsistent and inconclusive overall.

Research further suggests Magnesium supplementation may significantly reduce arterial stiffness. A 24-week randomized controlled trial with 350 mg/day Magnesium citrate reduced pulse wave velocity from 9.1 to 8.3 m/s versus placebo, and Magnesium also plays a role in endothelial function and vascular calcification prevention.

Nervous System

Magnesium is fundamental to nervous system function, acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability, neuromuscular transmission, and nerve signaling. Hypomagnesemia is clinically associated with neuromuscular hyperexcitability, tremors, and seizures, and Magnesium deficiency is linked to neurological disorders ranging from migraine to depression.

Research suggests Magnesium plays a critical role in nerve excitability by blocking NMDA receptors and regulating calcium and potassium channels. Clinical evidence supports Magnesium supplementation for nerve excitability modulation and neuropathic pain reduction. Magnesium is also an essential cofactor in dopamine synthesis and supports inhibitory-excitatory neurotransmitter balance.

Kidney Health

The kidneys are the primary site of Magnesium excretion and the major regulator of whole-body Magnesium homeostasis — typically only 3–5% of filtered Mg is excreted in urine. Research suggests Magnesium is a well-established inhibitor of calcium oxalate crystallization in urine. A landmark double-blind RCT of potassium-Magnesium citrate (n=64, up to 3 years) showed new stones formed in only 12.9% of treated subjects versus 63.6% on placebo. Magnesium supplementation also reduces urinary oxalate excretion and raises urinary citrate, both key protective factors against stone formation.

This Magnesium Complex supplement may be a good fit for several groups of people. Research suggests that certain populations are more likely than others to have Magnesium inadequacy, including older adults (due to decreased absorption), individuals with gastrointestinal disorders, those with type 2 diabetes, people with alcohol dependence, and individuals on certain long-term medications such as diuretics or proton pump inhibitors.

Adults concerned about cardiovascular wellness may find this formula particularly relevant. Higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across multiple meta-analyses. Magnesium is also a well-established cofactor in cardiac electrophysiology, and deficiency is linked to arrhythmias.

Those looking to support healthy kidney function and urinary mineral balance may also benefit, as research suggests Magnesium supplementation inhibits calcium oxalate crystallization in urine and supports protective urinary citrate levels.

If you're uncertain whether a Magnesium Complex supplement is right for your individual needs, our naturopath is available for a free consultation to help you make an informed decision.

Take 2 capsules twice daily with a meal. Each serving of 2 capsules provides 184 mg of Magnesium from both Magnesium citrate and Magnesium malate forms.

The Recommended Dietary Allowance (RDA) for Magnesium is 400–420 mg/day for adult men and 310–320 mg/day for adult women. The Tolerable Upper Intake Level (UL) for supplemental Magnesium is 350 mg — this applies to Magnesium from supplements and medications only, not Magnesium found naturally in food and beverages.

It is worth noting that Magnesium can interact with certain medications. If you take bisphosphonates, tetracycline or quinolone antibiotics, diuretics, proton pump inhibitors, or gabapentin, you should be aware that Magnesium may affect absorption or effectiveness of these medications. Separating doses by at least 2 hours (or 4–6 hours for certain antibiotics) is generally recommended. If you are on any medications, consider discussing Magnesium supplementation with a healthcare professional or our naturopath through a free consultation.