Magnesium Complex Nature Made | Dual-Form Support

Magnesium Complex is a dual-form Magnesium supplement from Nature's Sunshine that pairs two highly bioavailable organic forms — Magnesium citrate and Magnesium malate — in a single capsule. With 184 mg of Magnesium per two-capsule serving, this formula is designed to support the cardiovascular system, brain function, kidney health, and muscles.

Magnesium is the fourth most abundant cation in the human body and a critical cofactor in more than 300 enzymatic reactions. It regulates energy metabolism, neuromuscular function, cardiovascular health, bone integrity, immune defense, and psychological well-being. Despite its importance, an estimated 56–68% of Americans do not obtain enough Magnesium daily to meet the recommended dietary allowance.

The choice of citrate and malate forms matters. Organic Magnesium salts — such as citrate and malate — are generally more soluble and have higher bioavailability than inorganic forms like Magnesium oxide. Research confirms that Magnesium citrate has high solubility even in water (55%) and is substantially more soluble than Magnesium oxide in all states of acid secretion. This high solubility is why the Magnesium Complex label highlights that the formula is "highly soluble," supporting efficient absorption.

If you have questions about whether a Magnesium Complex is right for your wellness routine, our naturopath is available for a free consultation to help you think through your individual needs.

Magnesium Complex delivers its 184 mg of elemental Magnesium through two complementary organic forms — Magnesium citrate and Magnesium malate. Both belong to the category of organic Magnesium salts, meaning the Magnesium ion is chelated to organic acid molecules. These organic forms are generally more soluble and better absorbed than inorganic counterparts.

Cardiovascular Support

Research suggests that higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease. Magnesium regulates cardiac ion channels, myocardial conduction, and contraction. A well-established cofactor in cardiac electrophysiology, it modulates ion channel exchanges and action potentials. Hypomagnesemia is strongly linked to ventricular and supraventricular arrhythmias. Multiple meta-analyses and randomized controlled trials form the evidence base for Magnesium's role in cardiovascular health.

Studies also suggest that Magnesium supplementation may significantly reduce arterial stiffness. A 24-week RCT using 350 mg/day of Magnesium citrate reduced pulse wave velocity from 9.1 to 8.3 m/s versus placebo. Magnesium also plays a role in endothelial function, participates in vascular calcification prevention, and may improve flow-mediated dilation.

Nervous System Support

Magnesium is fundamental to nervous system function, acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability, neuromuscular transmission, and nerve signaling. Deficiency is clinically associated with neuromuscular hyperexcitability, tremors, and seizures. Magnesium also plays a critical role in nerve excitability by regulating calcium and potassium channels, and research suggests supplementation may support nerve excitability modulation.

Muscle Function

Magnesium is an essential cofactor for ATP synthesis and utilization, muscle contraction, and electrolyte homeostasis. Deficiency is associated with muscle cramps, weakness, and impaired exercise performance. Magnesium deficiency impairs muscle relaxation, as muscles may contract normally but struggle to fully release when levels are low. A 2024 systematic review of four RCTs found that Magnesium supplementation reduced muscle soreness, improved performance and recovery, and exerted a protective effect on muscle damage in physically active individuals.

Because Magnesium plays such a wide-ranging role in the body, many adults may benefit from supplementation — especially given that the diets of most people in the United States provide less than the recommended amounts of this mineral. The RDA for adult men is 400–420 mg/day, while for adult women it is 310–320 mg/day.

Certain groups face a higher risk of Magnesium inadequacy. These include older adults (due to decreased absorption from food and increased medication use), individuals with gastrointestinal disorders, those with type 2 diabetes, people with alcohol dependence, and individuals on certain long-term medications such as diuretics or proton pump inhibitors. Men older than 70 and teenage girls are most likely to have low intakes.

Early signs and symptoms of Magnesium deficiency include loss of appetite, nausea, fatigue, and weakness. As deficiency worsens, numbness, tingling, muscle contractions and cramps, personality changes, and abnormal heart rhythms can occur.

Magnesium Complex may be particularly relevant for adults looking to support cardiovascular function, maintain normal muscle relaxation and nerve signaling, or simply help bridge the gap between what they eat and what their body needs. If you're unsure whether supplementing with Magnesium is appropriate for you — especially if you take medications — our naturopath offers free consultations to help you sort through the details.

Take 2 capsules twice daily with a meal.

Each bottle contains 100 capsules. Two capsules provide 184 mg of Magnesium from both Magnesium citrate and Magnesium malate.

Important safety notes: Magnesium supplements can cause nausea, cramps, and diarrhea, particularly at higher doses. Side effects are more common with inorganic forms such as Magnesium oxide; the organic citrate and malate forms in this product are generally better tolerated.

Several medications may interact with Magnesium supplements. Magnesium can decrease the absorption of bisphosphonates (separate by at least 2 hours), tetracycline and quinolone antibiotics (take the antibiotic at least 2 hours before or 4–6 hours after Magnesium), and gabapentin (may reduce absorption by 20%). Loop and thiazide diuretics may deplete Magnesium through increased urinary excretion, while long-term proton pump inhibitor (PPI) use can cause hypomagnesemia. If you take any medications, consult your healthcare provider before starting Magnesium supplementation.