Magnesium Complex | Heart, Brain & Kidney Support

Magnesium Complex is a dual-form Magnesium supplement that combines Magnesium citrate and Magnesium malate — two organic, highly soluble forms of this essential mineral — to support the cardiovascular system, brain function, and kidney health. Two capsules deliver 184 mg of Magnesium in forms your body can readily absorb.

Magnesium is the fourth most abundant cation in the human body and serves as a cofactor in more than 300 enzyme systems that regulate everything from energy production and protein synthesis to muscle and nerve function, blood glucose control, and blood pressure regulation. It is indispensable for ATP synthesis, the fundamental energy currency of every cell.

Despite its vital importance, emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for Magnesium. The diets of most people in the United States provide less than recommended amounts, with men older than 70 and teenage girls most likely to fall short. This widespread shortfall makes thoughtful supplementation especially relevant.

If you have questions about whether a Magnesium supplement is right for your individual needs, our naturopath is available for a free consultation — we're always happy to help you think it through.

Cardiovascular System

Research suggests Magnesium plays a well-documented role in cardiovascular health. Higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across large meta-analyses and prospective cohort studies. In 2022, the U.S. FDA approved a qualified health claim stating that consuming diets with adequate Magnesium may reduce the risk of high blood pressure, though the agency noted the evidence is inconsistent and inconclusive.

Magnesium is also a well-established cofactor in cardiac electrophysiology, modulating ion channel exchanges and action potentials. Hypomagnesemia is strongly linked to ventricular and supraventricular arrhythmias. A meta-analysis of 22 studies found Magnesium sulfate significantly reduced ventricular arrhythmias (11.88% vs 24.24%) and supraventricular arrhythmias compared to placebo.

Studies also suggest Magnesium supplementation may significantly reduce arterial stiffness. A 24-week RCT using 350 mg/day Magnesium citrate reduced pulse wave velocity from 9.1 to 8.3 m/s versus placebo. Magnesium also plays a role in endothelial function, vascular calcification prevention, and flow-mediated dilation.

Nervous System and Brain Function

Magnesium is fundamental to nervous system function, acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability, neuromuscular transmission, and nerve signaling. Hypomagnesemia is clinically associated with neuromuscular hyperexcitability, tremors, and seizures, and deficiency is linked to neurological concerns ranging from migraine to mood imbalance.

Research suggests Magnesium is an essential cofactor in dopamine synthesis via tyrosine hydroxylase and a physiological blocker of NMDA glutamate receptor channels. A 2017 RCT showed 248 mg/day Magnesium significantly reduced both depression and anxiety scores, supporting its role in inhibitory-excitatory neurotransmitter balance.

Kidney Health

The kidneys are the primary site of Magnesium excretion and the major regulator of whole-body Magnesium homeostasis — typically only 3–5% of filtered Magnesium is excreted in urine. Higher urinary Magnesium from adequate dietary intake is also associated with reduced risk of kidney stone formation.

Research suggests Magnesium is a well-established inhibitor of calcium oxalate crystallization in urine. A landmark double-blind RCT of potassium-Magnesium citrate (n=64, up to 3 years) showed new stones formed in only 12.9% of treated subjects versus 63.6% on placebo. Magnesium supplementation also reduces urinary oxalate excretion and raises urinary citrate, both key protective factors against stone formation.

Magnesium Complex pairs Magnesium citrate and Magnesium malate — both organic forms that are generally more soluble and have higher bioavailability than inorganic alternatives like Magnesium oxide. Research has shown that Magnesium citrate has high solubility even in water (55%) and was substantially more soluble than Magnesium oxide in all states of acid secretion.

Organic forms of Magnesium involve the mineral chelated to organic molecules such as organic acids. This chelation supports efficient absorption in the gut. By combining two distinct organic carriers — citric acid and malic acid — Magnesium Complex offers a highly soluble formula designed for optimum effectiveness.

For comparison, inorganic forms like Magnesium oxide are the most concentrated by weight but have lower bioavailability. Magnesium oxide was found to be virtually insoluble in water and only 43% soluble in simulated peak acid secretion. The organic forms in Magnesium Complex avoid these absorption limitations.

Magnesium Complex is designed for adults looking to support their heart, brain, and kidney health with a highly soluble, well-absorbed Magnesium supplement. It may be particularly relevant for:

• Adults concerned about cardiovascular wellness — research suggests adequate Magnesium supports healthy blood pressure, arterial flexibility, and normal heart rhythm.
• Older adults — as we age, Magnesium absorption and retention can decrease, and medication use (such as diuretics or proton pump inhibitors) may further deplete stores. Men older than 70 are among those most likely to have low Magnesium intakes.
• Those with kidney stone concerns — studies suggest Magnesium, particularly as citrate, may help inhibit calcium oxalate crystal formation in the urinary tract.
• Anyone who may not get enough Magnesium from diet alone — an estimated 56–68% of Americans do not obtain enough Magnesium daily to meet the recommended dietary allowance.
• People seeking nervous system support — Magnesium's role as a natural NMDA receptor antagonist may support normal nerve function and neuronal excitability.

If you're taking medications such as bisphosphonates, tetracycline or quinolone antibiotics, diuretics, proton pump inhibitors, or gabapentin, be aware that Magnesium may interact with these drugs. Our naturopath can help you evaluate whether Magnesium Complex fits your current regimen — just reach out for a free consultation.

Take 2 capsules twice daily with a meal. Each bottle contains 100 capsules.

Two capsules provide 184 mg of Magnesium from both citrate and malate forms. For reference, the Recommended Dietary Allowance for Magnesium is 400–420 mg/day for adult men and 310–320 mg/day for adult women.

Magnesium supplements are generally well tolerated. The most common side effects — which tend to occur at higher doses — include softening of stool, nausea, or cramping. Organic forms like citrate and malate are associated with fewer gastrointestinal side effects than inorganic forms such as Magnesium oxide.

If you take bisphosphonates (such as alendronate), separate your doses by at least 2 hours. If you take tetracycline or quinolone antibiotics, take the antibiotic at least 2 hours before or 4–6 hours after Magnesium. Individuals with impaired kidney function should consult a healthcare professional before supplementing, as the kidneys are responsible for clearing excess Magnesium.