Magnesium Complex | Heart, Brain & Kidney Support

Magnesium Complex is a dual-form Magnesium supplement designed to support the brain, heart, and kidneys with this essential mineral. It pairs two organic forms of Magnesium — Magnesium citrate and Magnesium malate — both of which are highly soluble and efficiently absorbed by the body. Two capsules deliver 184 mg of Magnesium.

Magnesium is the fourth most abundant cation in the human body and serves as a cofactor in more than 300 enzyme systems that regulate everything from energy production and protein synthesis to muscle and nerve function, blood glucose control, and blood pressure regulation. It is required for ATP synthesis, ion transport, bone metabolism, and neurological function.

Despite its critical importance, an estimated 56 to 68% of Americans do not obtain enough Magnesium from their daily diet to meet the recommended daily allowance. Magnesium deficiency is associated with a range of health concerns, including cardiovascular abnormalities, muscle cramps, fatigue, and neurological symptoms. This widespread shortfall makes thoughtful supplementation especially relevant.

Magnesium Complex uses organic salt forms — citrate and malate — rather than inorganic forms like Magnesium oxide. Organic forms are generally more soluble and have higher bioavailability. Research has shown that Magnesium citrate has high solubility even in water (55%) and is substantially more soluble than Magnesium oxide in all states of acid secretion, making it an excellent choice for absorption.

Cardiovascular Support

Research suggests that Magnesium plays a well-documented role in cardiovascular health. Higher dietary and circulating Magnesium levels are inversely associated with risks of coronary heart disease, stroke, and total cardiovascular disease across multiple large meta-analyses and prospective cohort studies. Magnesium regulates cardiac ion channels, myocardial conduction, and contraction, and hypomagnesemia is directly linked to arrhythmias and increased cardiovascular risk.

Studies suggest that Magnesium supplementation may produce modest but significant reductions in blood pressure, particularly in Magnesium-deficient or hypertensive individuals. A 2021 systematic review of 49 clinical trials confirmed antihypertensive effects through mechanisms including vasodilation, calcium channel antagonism, and RAAS modulation. Research also indicates that Magnesium supplementation may significantly reduce arterial stiffness — a 24-week RCT with 350 mg/day Magnesium citrate reduced pulse wave velocity from 9.1 to 8.3 m/s versus placebo.

A meta-analysis of 22 studies found that Magnesium supplementation significantly reduced both ventricular arrhythmias (11.88% vs 24.24%) and supraventricular arrhythmias compared to placebo. Magnesium is a well-established cofactor in cardiac electrophysiology, modulating ion channel exchanges and action potentials.

Nervous System and Brain Support

Magnesium is fundamental to nervous system function, acting as a physiological NMDA receptor antagonist and regulator of neuronal excitability, neuromuscular transmission, and nerve signaling. Hypomagnesemia is clinically associated with neuromuscular hyperexcitability, tremors, and seizures, and deficiency is linked to neurological disorders ranging from migraine to depression.

Magnesium also plays a critical role in nerve excitability by blocking NMDA receptors and regulating calcium and potassium channels. Clinical evidence supports its role in nerve excitability modulation and neuropathic pain reduction. As a cofactor in dopamine synthesis (tyrosine hydroxylase) and a blocker of NMDA glutamate receptor channels, Magnesium supports inhibitory-excitatory neurotransmitter balance.

Kidney Health

The kidneys are the primary site of Magnesium excretion and the major regulator of whole-body Magnesium homeostasis — typically only 3–5% of filtered Magnesium is excreted in urine. Higher urinary Magnesium from adequate dietary intake is associated with reduced risk of kidney stone formation.

Research suggests Magnesium is a well-established inhibitor of calcium oxalate crystallization in urine. A landmark double-blind RCT of potassium-Magnesium citrate (n=64, up to 3 years) showed new stones formed in only 12.9% of treated subjects versus 63.6% on placebo (relative risk 0.16). Magnesium supplementation also reduces urinary oxalate excretion and raises urinary citrate, both key protective factors against stone formation.

Magnesium Complex may be especially relevant for anyone looking to support their heart, brain, or kidney health with a highly absorbable Magnesium supplement. Given that an estimated 56 to 68% of Americans fall short of the recommended daily allowance for Magnesium, many adults may benefit from supplementation.

Certain groups are more likely to have inadequate Magnesium levels. Older adults face decreased absorption from food and increased medication use — diuretics, for example, can deplete Magnesium through increased urinary excretion. Individuals with type 2 diabetes, gastrointestinal disorders, alcohol dependence, or those taking long-term proton pump inhibitors (PPIs) are also at elevated risk for deficiency.

Early signs of Magnesium deficiency include loss of appetite, nausea, fatigue, and weakness. As deficiency worsens, numbness, tingling, muscle cramps, personality changes, and abnormal heart rhythms can develop. If you're unsure whether Magnesium supplementation is right for you, our naturopath is available for a free consultation to help you evaluate your individual needs.

Take 2 capsules twice daily with a meal.

Each bottle contains 100 capsules. Two capsules provide 184 mg of Magnesium from both citrate and malate forms.

Magnesium supplements can occasionally cause stomach-related effects such as softening of stool, nausea, or cramping, particularly at higher doses. These effects are more common with inorganic forms like Magnesium oxide and are generally less frequent with organic forms like the citrate and malate used in this formula.

Important drug interactions to be aware of: Magnesium may interact with certain medications. If you take bisphosphonates (e.g., alendronate), separate doses by at least 2 hours. If you take tetracycline or quinolone antibiotics, take the antibiotic at least 2 hours before or 4–6 hours after Magnesium. Loop and thiazide diuretics can deplete Magnesium, while long-term proton pump inhibitor (PPI) use may cause low Magnesium levels. Magnesium may also reduce the absorption of gabapentin by approximately 20%. Consult your healthcare provider if you take any of these medications.