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How Does Lymphatic Drainage Work | Nature’s Sunshine

Learn how does Lymphatic Drainage work with Cleavers, Red clover, Stillingia root & Prickly ash bark. Explore the herbs that traditionally support lymph flow.

Understanding the System

How Does Lymphatic Drainage Work

Your lymphatic system is a network of tissues and organs that helps keep your body healthy by removing waste from cellular metabolism. Unlike the cardiovascular system, which has the heart as its pump, the lymphatic system relies on movement, muscle contraction, and proper fluid balance to keep lymph flowing. When this system becomes sluggish, waste products can accumulate and fluid balance may be disrupted.

So how does Lymphatic Drainage work from a botanical perspective? For centuries, herbalists across European, Native American, and Traditional Chinese Medicine traditions have turned to specific plants believed to encourage lymph fluid movement, support the body's natural detoxification pathways, and promote healthy fluid distribution. Nature's Sunshine Lymphatic Drainage brings four of these historically revered herbs together in a convenient liquid formula: Cleavers aerial parts, Red clover blossom extract, Stillingia root, and Prickly ash bark.

This formula is designed to aid the proper dispersion of lymphatic fluid and support overall health and well-being, including the circulatory system. If you have questions about whether this formula is right for your needs, our naturopath is available for a free consultation.

What's inside

Key ingredients

Cleavers aerial parts β€” 300 mg
Cleavers (Galium aparine L.) is an annual herbaceous plant of the Rubiaceae family, native to Europe, North Africa, and Asia, that has been a cornerstone of Western herbal medicine for centuries. Its aerial parts β€” stems, leaves, and flowers β€” are rich in iridoid glycosides (including asperuloside), flavonoids, coumarins, tannins, and polyphenolic acids. Coumarins present in Galium species are traditionally understood to promote Lymphatic Drainage, while the high concentrations of flavonoids, phenols, and tannins confirm a substantial antioxidant capacity in laboratory studies. Cleavers is the primary lymphatic tonic in Western herbal medicine, with thousands of years of cross-cultural use to encourage lymph fluid movement, drain congested lymph nodes, and support detoxification. Herbalists have historically prescribed it for swollen lymph nodes, lymphedema, and lymphatic congestion. It is also one of the best-attested traditional diuretics, used historically for edema, dropsical swellings, and water weight β€” preclinical animal studies confirm increased urinary volume with extracts. Laboratory research has also demonstrated immunomodulatory activity: bioactive fractions made of polysaccharide, pectin, and polyphenolic complexes were shown to stimulate the activity of immunocompetent blood cells and increase the percentage of lymphocyte proliferation in vitro. While these traditional uses are long-standing and phytochemical evidence is supportive, human clinical trials specifically evaluating Cleavers for lymphatic outcomes have not been published.
Red clover blossom extract β€” 300 mg
Red clover (Trifolium pratense L.) is a perennial member of the legume family (Fabaceae) with a deep heritage in Western and naturopathic herbalism as a blood cleanser and lymphatic tonic. Its principal bioactives are isoflavones β€” biochanin A, formononetin, genistein, and daidzein β€” along with natural coumarins, a class of benzopyrones that have been studied for their relevance to vascular and lymphatic function. Traditionally, Red clover has been recommended for swollen glands, chronic lymphatic congestion, and skin eruptions thought to arise from lymphatic stagnation. Part of the class of herbs known as alteratives, Red clover traditionally supports the detoxification functions of the liver and lymphatic systems. Its isoflavones modulate NF-ΞΊB and MAPK signaling pathways relevant to vascular and lymphatic function, though modern research focuses primarily on cardiovascular and menopausal benefits rather than directly on lymphatic endpoints. Direct clinical evidence for lymphatic function remains traditional. Red clover is generally regarded as safe over the short-term duration studied in clinical trials, though individuals on anticoagulant medications or with hormone-sensitive conditions should consult their healthcare provider before use.
Stillingia root β€” 300 mg
Stillingia (Stillingia sylvatica L.) is a perennial plant of the Euphorbiaceae family, native to sandy pine barrens and coastal regions of the southeastern United States. The large woody root and rhizome are the parts used medicinally. It is one of the most consistently cited traditional lymphatic herbs in North American folk and Eclectic medicine, used to stimulate lymphatic flow and address lymphatic stagnation. King's American Dispensatory (1898) described Stillingia's action on the lymphatic system as unsurpassed, and Eclectic physicians employed it extensively for swollen lymph glands, scrofulous conditions, chronic skin eruptions, and what they termed 'constitutional weakness' characterized by sluggish elimination. It was believed to increase the action of the skin and the secretions of the kidneys and bowels. The root contains diterpene esters, tannins, resins, volatile oil, and an alkaloid called stillingine. Preliminary laboratory studies have investigated its anti-inflammatory and immunomodulatory properties, but no clinical studies in humans exist to validate these traditional uses. All documentation of lymphatic and alterative benefits is historical and traditional.
Prickly ash bark β€” 300 mg
Prickly ash (Zanthoxylum spp.) is an aromatic shrub or tree in the Rutaceae (citrus) family, traditionally known as the 'toothache tree' for the numbing, tingling sensation produced when its bark is chewed. The bark contains alkaloids (chelerythrine, berberine, nitidine), alkylamides (sanshools), coumarins, lignans, and flavonoids. In multiple professional herbal materia medica sources, Prickly ash is classified as a 'lymphatic stimulant.' Naturopathic herbal texts note that due to its stimulating effect upon the lymphatic system, circulation, and mucous membranes, it plays a role in the holistic treatment of many conditions. North American herbalists and 19th-century Eclectic physicians used Prickly ash bark widely to support peripheral circulation, digestive function, and rheumatic conditions, and it has historically been taken for blood circulation problems. This traditional herbal classification as a lymphatic stimulant does not have supporting human clinical evidence β€” the designation is based on long-standing herbal practice rather than modern clinical trials.
Lymphatic Drainage
Lymphatic Drainage
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A Traditional Approach

How These Four Herbs Work Together

Understanding how does Lymphatic Drainage work at the herbal level begins with the idea that different herbs can address different aspects of lymphatic wellness. Nature's Sunshine Lymphatic Drainage combines four botanicals with complementary traditional roles:

  • Cleavers β€” historically the primary lymphatic tonic in Western herbalism, traditionally used to encourage lymph fluid movement and drain congested lymph nodes.
  • Red clover β€” a classic alterative, traditionally used to support the detoxification functions of the liver and lymphatic systems, and to address swollen glands and chronic lymphatic congestion.
  • Stillingia root β€” considered by Eclectic physicians to have an unsurpassed action on the lymphatic system, traditionally used for lymphatic stagnation and sluggish elimination.
  • Prickly ash bark β€” classified in herbal materia medica as a lymphatic stimulant with a traditional focus on circulation and mucous membrane support.

Together, these herbs represent a broad spectrum of the Western herbal tradition's approach to lymphatic wellness. The formula also aids the circulatory system and supports overall health and well-being.

It is important to note that these benefits are rooted in centuries of traditional herbalism. Modern research has begun to explore the phytochemistry behind many of these plants β€” identifying constituents such as iridoids, isoflavones, coumarins, and alkaloids β€” but large-scale human clinical trials specifically evaluating lymphatic outcomes remain limited.

Is It Right for You?

Who May Benefit from Lymphatic Drainage Support

Nature's Sunshine Lymphatic Drainage may appeal to individuals seeking traditional herbal support for their lymphatic system, healthy fluid balance, and overall well-being. Because the lymphatic system plays a role in removing waste from cellular metabolism, those interested in supporting their body's natural detoxification pathways may find this formula particularly relevant.

People interested in traditional approaches to water retention and fluid balance may also consider this product, given Cleavers' long-standing cross-cultural reputation as a gentle herbal diuretic.

If you're unsure whether this formula fits your health goals, our naturopath offers free consultations and can help you determine a path forward. Individuals who are pregnant, nursing, taking anticoagulant medications, or managing any health condition should consult their healthcare provider before use, as several of these herbs carry specific contraindications.

How to Use

Directions for Lymphatic Drainage

Take 1 ml (approximately 15–20 drops, 1/4 teaspoon) in water twice daily.

Each bottle provides 2 fl oz of liquid extract. The serving size is 1 mL, delivering 300 mg each of Cleavers aerial parts, Red clover blossom extract, Stillingia root, and Prickly ash bark per serving.

About the author

Written by Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

How does Lymphatic Drainage work as an herbal supplement?

Nature's Sunshine Lymphatic Drainage uses four herbs β€” Cleavers, Red clover, Stillingia root, and Prickly ash bark β€” that have been traditionally used in Western herbalism to aid the proper dispersion of lymphatic fluid. These herbs are historically classified as lymphatic tonics, alteratives, and lymphatic stimulants, each bringing a complementary role to supporting the body's lymphatic system. While phytochemical studies have identified relevant constituents like iridoids, isoflavones, and coumarins, human clinical trials specifically evaluating lymphatic outcomes with these herbs remain limited.

What does the lymphatic system do in the body?

The lymphatic system helps keep the body healthy by removing waste from cellular metabolism. It plays a role in fluid balance, immune function, and the transport of waste products away from tissues. Nature's Sunshine Lymphatic Drainage contains nutrients designed to aid this process for better well-being.

What is Cleavers and why is it in this formula?

Cleavers (Galium aparine) is the primary lymphatic tonic in Western herbal medicine, with thousands of years of use across European, Native American, and Traditional Chinese Medicine traditions to encourage lymph fluid movement and drain congested lymph nodes. It is also traditionally valued as a gentle diuretic, historically used for edema and water weight. Its aerial parts contain iridoid glycosides, flavonoids, coumarins, and tannins. While preclinical studies support some of these traditional uses β€” including immunomodulatory activity in laboratory settings β€” clinical trials evaluating lymphatic outcomes in humans have not been published.

Are there any safety considerations with this formula?

Several of the herbs in this formula carry specific safety considerations. Cleavers may interact with diuretic medications and is not recommended during pregnancy due to limited safety data. Red clover may interact with anticoagulant drugs and should be avoided by individuals with hormone-sensitive conditions. Stillingia is contraindicated during pregnancy or lactation. Prickly ash is contraindicated during pregnancy and for those on anticoagulant therapy. If you have any health condition or take medications, consult your healthcare provider before use. Our naturopath is also available for a free consultation to discuss your individual needs.

Can this supplement help with water retention?

Cleavers, one of the key ingredients in this formula, has a long-standing traditional reputation as a gentle diuretic used to support healthy fluid balance. Preclinical animal studies have confirmed increased urinary volume with Cleavers extracts. However, human clinical trials evaluating this specific effect are lacking. Individuals experiencing edema due to impaired heart or kidney function should consult their healthcare provider before using diuretic herbs.

How is this formula different from a Lymphatic Drainage massage?

Nature's Sunshine Lymphatic Drainage is a liquid herbal supplement taken internally that contains traditional lymphatic herbs β€” Cleavers, Red clover, Stillingia root, and Prickly ash bark β€” designed to aid the proper dispersion of lymphatic fluid from the inside. Lymphatic Drainage massage is a manual, external therapy. They represent different approaches, and some individuals may choose to incorporate both as part of their wellness routine. Consult your healthcare provider to determine what's appropriate for you.

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