What Does Magnesium Do for the Body? A Deep Dive

If you've ever wondered what does Magnesium do for the body, the short answer is: a lot. Magnesium is the fourth most abundant cation in the human body and a critical cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It's found in the bones, soft tissues, and blood — touching virtually every system you rely on daily.

Nature's Sunshine Magnesium is formulated to support nervous system health, promote healthy bone density, and help with muscle comfort. It provides 250 mg of Magnesium from both Magnesium oxide and Magnesium amino acid chelate, set in a base of Licorice root, Kelp plant, Peppermint leaves, and White willow bark. It also supplies 40 mg of Calcium and 30 mg of Phosphorus — two minerals that work in concert with Magnesium throughout the body.

Despite Magnesium's essential roles, emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance. Men older than 70 and teenage girls are most likely to have low intakes. Because Magnesium is required for energy production, oxidative phosphorylation, and glycolysis — and because it helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium — even modest shortfalls can affect how you feel day to day.

Nervous system support. Magnesium is a natural NMDA receptor antagonist, modulating synaptic transmission and neuronal excitability. It regulates neuronal excitability through voltage-gated Calcium antagonism and NMDA receptor blockade. When Magnesium levels drop, neuromuscular hyperexcitability, tremors, and even seizures may occur. Research suggests that adequate Magnesium supports normal nerve function and may help reduce migraine frequency, though further study is ongoing.

Bone density. Magnesium is involved in bone formation and influences the activities of osteoblasts and osteoclasts. It also affects the concentrations of both parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis. Observational data from large cohort studies have found that higher Magnesium intake is associated with 2–3% greater bone density in women. Calcium and Magnesium are nutritional partners and work best when taken together, which is why this formula includes both.

Muscle relaxation and comfort. Magnesium deficiency impairs muscle relaxation — muscles contract normally but struggle to fully release when levels are low. A 2024 systematic review found that Magnesium supplementation reduced muscle soreness, improved performance and recovery, and exerted a protective effect on muscle damage in physically active individuals. The formula is also highlighted as a muscle relaxant that may promote proper elimination.

Energy production. Mg²⁺ plays a pivotal role in ATP synthesis catalyzed by ATP synthases, making it indispensable for cellular energy generation across virtually all tissues. This is one reason the product highlights its role in boosting energy production.

Magnesium plays such a wide role in the body that many people may find it supportive. Based on the research, certain groups are more likely to have Magnesium inadequacy, including:

• Older adults — As we age, Magnesium absorption and retention can decrease, leading to deficiency and potential health consequences.
• Those with active lifestyles — Exercise may increase Magnesium requirements by 10–20%, and a 2024 review found supplementation may support muscle recovery and reduce soreness.
• People concerned about bone health — Magnesium influences osteoblast and osteoclast activity and is required for vitamin D activation. People with higher levels of Magnesium may have higher bone mineral density, which is important in helping reduce the risk of bone fractures associated with osteoporosis.
• Individuals on certain medications — Several drugs, including diuretics and proton-pump inhibitors, can cause Magnesium loss.
• Anyone not meeting the RDA through diet — It is estimated that between 56 and 68% of Americans do not obtain enough Magnesium in their diet on a daily basis.

If you're unsure whether Magnesium supplementation is right for you, our naturopath offers free consultations and can help you evaluate your individual needs.

Take 1 tablet daily with a meal. Each bottle contains 180 tablets.

This product provides 250 mg of Magnesium per serving alongside 40 mg of Calcium and 30 mg of Phosphorus. Because Calcium and Magnesium are nutritional partners and work best when taken together, the inclusion of Calcium in the formula supports optimal utilization of both minerals.