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Magnesium Chloride Guide | Benefits & Uses

Learn how Magnesium chloride supports nervous system health, bone density, and muscle relaxation. Explore key ingredients, benefits, and how to take it.

Overview

What Is Magnesium and Why Does It Matter?

Magnesium is the fourth most abundant cation in the human body and a critical cofactor in hundreds of enzymatic reactions that regulate energy metabolism, neuromuscular function, cardiovascular health, bone integrity, and psychological well-being. Nature's Sunshine Magnesium provides nervous system support and assists in a variety of bodily functions—making Magnesium chloride and related bioavailable forms essential daily nutrients.

Used by several hundred enzymes in their daily tasks, Magnesium is found in the bones, soft tissues, and blood. It helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium. Research confirms that Magnesium is a cofactor in more than 300 enzyme systems that regulate protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation.

Despite Magnesium's essential roles, emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance—a deficiency problem contributing to various health conditions. If you're unsure whether your intake is adequate, our naturopath is available for a free consultation to help you assess your needs.

How It Works

Nervous System, Bone Density, and Muscle Support

This formula is built around three core areas of support: nervous system health, bone density, and muscle cramps. Nature's Sunshine Magnesium comes in 250 mg capsules of Magnesium oxide and Magnesium amino acid chelate in a base of Licorice root, Kelp plant, Peppermint leaves, and White willow bark.

Magnesium is fundamental to nervous system function, acting as a natural NMDA receptor antagonist that modulates synaptic transmission and neuronal excitability. Research suggests that deficiency is associated with increased risk of neurological symptoms, and supplementation supports normal nerve function.

For bone density, Magnesium is an essential cofactor in bone mineral metabolism, enzyme activity for bone matrix synthesis, and is required for vitamin D activation. Observational data from large cohort studies found higher Magnesium intake associated with 2–3% greater bone density in women. Studies including the COMB study suggest supplementation may help attenuate bone loss.

Calcium and Magnesium are nutritional partners and work best when taken together. This formula includes both minerals, along with Phosphorus, to provide comprehensive skeletal and neuromuscular support.

Qué contiene

Key Ingredients

Magnesium — 250 mg
Magnesium is a cofactor in more than 300 enzyme systems regulating protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It is required for energy production, oxidative phosphorylation, and glycolysis. Research suggests Magnesium supports bone density—observational data from large cohort studies found higher intake associated with 2–3% greater bone density in women—and nervous system health, where it acts as a natural NMDA receptor antagonist modulating neuronal excitability. Magnesium deficiency impairs muscle relaxation, as muscles contract normally but struggle to fully release when levels are low; supplementation in deficient individuals may help restore muscle function. A 2024 systematic review found Magnesium supplementation reduced muscle soreness, improved performance and recovery, and exerted a protective effect on muscle damage in physically active individuals. Magnesium also influences osteoblast and osteoclast activity and affects concentrations of both parathyroid hormone and active vitamin D, which are major regulators of bone homeostasis.
Calcium — 40 mg
Calcium is the most abundant mineral in the human body, with more than 99% stored in bone as hydroxyapatite. It is essential for skeletal strength, muscle contraction, neuronal transmission, and enzyme regulation. Research suggests Calcium supplementation significantly improves bone mineral density (BMD), particularly in people under 35 building peak bone mass. Combined with vitamin D, it may attenuate bone loss in older adults. Calcium is also essential for muscle contraction and relaxation—hypocalcemia is recognized as a cause of muscle cramps, tetany, and spasms in standard medical references. Calcium ions play a key role in the central nervous system as part of the neurotransmission mechanism, stabilizing membrane potential and controlling neuronal excitability.
Phosphorus — 30 mg
Phosphorus is the second most abundant mineral in the human body, with approximately 85% stored in bones and teeth as hydroxyapatite. Together with Calcium, it forms the mineral matrix that gives bones and teeth their structural integrity. Phosphorus is a building block of DNA, RNA, and ATP—the body's primary energy source—and helps activate enzymes, maintain normal blood pH, and regulate nerve and muscle function. Phospholipids containing Phosphorus are primary components of neuronal cell membranes and are required for synaptic neurotransmission. Adequate dietary Phosphorus is universally recognized as essential for bone mineralization and maintaining bone mineral density.
Kelp leaf and stem
Kelp is a brown seaweed (order Laminariales) that has been used traditionally for centuries. The Japanese have incorporated Kelp into their diets for 1,500 years, and indigenous peoples of the Pacific Northwest traditionally used various Kelp species to support health. Kelp is a rich source of naturally occurring minerals, including iodine, and contains bioactive polysaccharides such as alginic acid, laminarin, and fucoidan. Historically, Kelp was used by multiple cultures for its mineral content and as part of traditional wellness practices.
Licorice root
Licorice root (Glycyrrhiza glabra) has been used worldwide as a traditional medicine for over 4,000 years, with documented use in ancient Assyrian, Egyptian, Greek, Chinese, and Indian cultures. It was traditionally used for coughing, sore throats, and digestive support. In traditional Chinese medicine, licorice appears in approximately 60% of prescriptions. Licorice root contains glycyrrhizin and over 300 active compounds, including flavonoids. The German Commission E approves the use of licorice for catarrhal conditions of the upper respiratory tract, and it has historically been valued for its soothing and digestive properties.
Peppermint leaves
Peppermint (Mentha × piperita) is a hybrid mint with a long medicinal history stretching back to ancient Egypt, where dried Peppermint leaves were found in pyramids dating to 1000 B.C. The Ebers Papyrus (c. 1550 BC) documents its carminative and digestive use. The ancient Greeks and Romans valued it as a stomach soother. Peppermint contains menthol, which has traditionally been used to support digestive comfort. The German Commission E approved Peppermint leaf for spastic complaints of the gastrointestinal tract.
White willow bark
White willow bark (Salix alba) has a history spanning more than 3,500 years, with use by Sumerians, Egyptians, and ancient Greeks for comfort and well-being. Hippocrates reportedly prescribed willow bark for fever and pain. The bark contains salicin, a natural salicylate derivative, along with polyphenols and flavonoids. Native American tribes throughout North America used various willow species traditionally. The European Medicines Agency recognizes willow bark preparations under a traditional-use framework for adults.
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Who Benefits

Who May Benefit from Magnesium Supplementation?

This formula may be a good fit for adults looking for everyday support in three interconnected areas: nervous system health, bone density, and muscle comfort. Since Magnesium is a cofactor in more than 300 enzyme systems, virtually every body system depends on adequate levels.

Research suggests that certain groups are more likely to have Magnesium inadequacy, including older adults (due to decreased absorption), individuals with gastrointestinal concerns, those with type 2 diabetes, and people on certain long-term medications such as diuretics or proton pump inhibitors. Men older than 70 and teenage girls are also most likely to have low intakes of Magnesium.

It is estimated that between 56 and 68% of Americans do not obtain enough Magnesium in their diet on a daily basis to meet the recommended daily allowance. If you're wondering whether Magnesium chloride or another form might be right for your situation, our naturopath offers free consultations to help you sort through the options.

Directions

How to Take Nature's Sunshine Magnesium

Take 1 tablet daily with a meal. Each bottle contains 180 tablets, providing a generous six-month supply at the recommended serving size of one tablet per day.

Because Calcium and Magnesium are nutritional partners and work best when taken together, this formula conveniently combines both minerals in a single tablet alongside Phosphorus and a supportive herbal base. Vitamin D and Magnesium help the body better absorb Calcium, so maintaining adequate vitamin D status may further support your results.

Sobre el autor

Escrito por Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

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Preguntas frecuentes

How does Magnesium chloride compare to other forms of Magnesium?

Magnesium supplements come in many forms. According to the NIH, forms of Magnesium that are more easily absorbed by the body include Magnesium aspartate, Magnesium citrate, Magnesium lactate, and Magnesium chloride. Inorganic forms such as Magnesium oxide tend to have lower solubility and absorption rates, while organic forms are generally more bioavailable. This Nature's Sunshine formula uses Magnesium oxide and Magnesium amino acid chelate.

Why are Calcium and Magnesium included together?

Calcium and Magnesium are nutritional partners that work best when taken together. Magnesium is required for vitamin D activation and Calcium metabolism, while Calcium is the primary mineral constituent of bone. Research suggests that adequate intake of both minerals supports bone density and proper muscle function. Magnesium also helps the body better absorb Calcium.

What are the signs of Magnesium deficiency?

Early signs may include loss of appetite, nausea, vomiting, fatigue, and weakness. As Magnesium deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur. It is estimated that between 56 and 68% of Americans do not obtain enough Magnesium daily to meet the recommended allowance.

Can Magnesium supplements interact with medications?

Yes. Magnesium can form insoluble complexes with tetracycline and quinolone antibiotics, reducing their absorption—these should be separated by at least 2 hours. It may also decrease absorption of bisphosphonates and gabapentin. Loop and thiazide diuretics can deplete Magnesium, and prolonged use of proton pump inhibitors (PPIs) can cause low Magnesium levels. Always consult a healthcare professional about potential interactions with your current medications.

Does this product support muscle cramp relief?

This formula is designed to support muscle comfort. Magnesium deficiency impairs muscle relaxation, as muscles contract normally but struggle to fully release when levels are low. Additionally, Calcium is recognized as essential for muscle contraction and relaxation—hypocalcemia (low Calcium) is a known cause of muscle cramps and spasms. Together, these minerals may support healthy muscle function.

How much Magnesium do adults need daily?

The Recommended Dietary Allowance (RDA) for Magnesium is 400–420 mg per day for adult men and 310–320 mg per day for adult women. During pregnancy, requirements increase to about 350–360 mg daily. This formula provides 250 mg of Magnesium per tablet. If you're unsure about your total daily intake, our naturopath is happy to help during a free consultation.

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Magnesium Chloride Guide | Benefits & Uses