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Best Magnesium Glycinate | Nervous System & Bone Support

Discover the best Magnesium glycinate for nervous system health, bone density, and muscle cramps. Learn about key ingredients, benefits, and how to take it.

Why Magnesium Matters

Finding the Best Magnesium Glycinate for Everyday Wellness

Magnesium is the fourth most abundant cation in the human body and a critical cofactor in more than 300 enzyme systems that regulate energy metabolism, neuromuscular function, cardiovascular health, and bone integrity. Yet research suggests that between 56 and 68 percent of Americans do not obtain enough Magnesium in their daily diet to meet the Recommended Dietary Allowance.

When you're searching for the best Magnesium glycinate, you want a formula that not only delivers meaningful Magnesium but also pairs it with complementary nutrients and botanicals. Nature's Sunshine Magnesium provides 250 mg of Magnesium from both Magnesium oxide and Magnesium amino acid chelate, combined with Calcium, Phosphorus, and a supportive herbal base of Licorice root, Kelp, Peppermint leaves, and White willow bark — all in a convenient daily tablet.

This formula is designed to support nervous system health, bone density, and healthy muscle function. Magnesium helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium, while Calcium and Magnesium work as nutritional partners that perform best when taken together.

How It Works

Why This Formula Stands Out Among Magnesium Supplements

What sets the best Magnesium glycinate formulas apart is thoughtful ingredient pairing. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis — it plays a pivotal role in ATP synthesis, the fundamental energy currency of every cell. It also modulates neuronal excitability through NMDA receptor blockade and voltage-gated Calcium antagonism, helping maintain calm nervous system function.

In this formula, Calcium and Magnesium are united as nutritional partners. Calcium is the most abundant mineral in the body, with over 99 percent stored in bone as hydroxyapatite. Research suggests that Calcium is essential for both skeletal and smooth muscle contraction. Meanwhile, Phosphorus — the second most abundant mineral in bone — forms hydroxyapatite alongside Calcium to provide bones and teeth with structural integrity and strength.

The herbal base adds traditional dimension. Licorice root has been used for over 4,000 years in traditional medicine systems worldwide, while Peppermint leaves have been valued since ancient Egyptian times for digestive comfort. White willow bark has been traditionally used for centuries in European and Native American herbal traditions for general aches and muscle soreness.

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Key Ingredients

Magnesium — 250 mg
Magnesium is an essential mineral and cofactor in more than 300 enzyme systems that regulate protein synthesis, muscle and nerve function, blood glucose control, and blood pressure. It plays a pivotal role in ATP synthesis, making it indispensable for cellular energy generation. Research suggests that Magnesium is involved in bone formation and influences the activities of osteoblasts and osteoclasts, while also affecting concentrations of parathyroid hormone and active vitamin D — major regulators of bone homeostasis. Observational data from large cohort studies have found higher Magnesium intake associated with 2–3% greater bone density in women. A 2024 systematic review in the Journal of Translational Medicine found that Magnesium supplementation reduced muscle soreness, improved performance and recovery, and exerted a protective effect on muscle damage in physically active individuals. Magnesium also acts as a natural NMDA receptor antagonist, modulating synaptic transmission and neuronal excitability. In Nature's Sunshine Magnesium, it is delivered as Magnesium oxide and Magnesium amino acid chelate.
Calcium — 40 mg
Calcium is the most abundant mineral in the human body and the primary structural component of bone. More than 99% of Calcium is stored in bone as hydroxyapatite, providing skeletal strength. Studies suggest that Calcium is essential for both skeletal and smooth muscle contraction, operating via calmodulin-dependent activation of myosin light-chain kinase pathways. Hypocalcemia is recognized as a cause of muscle cramps, tetany, and spasms in standard medical references. In nerve cells, the intracellular Calcium signal is part of the neurotransmission mechanism — Calcium ions stabilize membrane potential and control neuronal excitability. Calcium and Magnesium are nutritional partners, and this formula includes both for complementary support.
Phosphorus — 30 mg
Phosphorus is the second most abundant mineral in the human body, with approximately 85% residing in bones and teeth as part of the hydroxyapatite mineral matrix. Together with Calcium, it provides structural integrity and strength to the skeleton. Phosphorus also functions in critical metabolic pathways: it helps produce and store energy in phosphate bonds (ATP), buffers blood pH, regulates gene transcription, and activates enzyme catalysis. Research confirms that Phosphorus regulates the normal function of nerves and muscles, including the heart, and that phospholipids containing Phosphorus are primary components of neuronal cell membranes required for synaptic neurotransmission.
Kelp leaf and stem
Kelp is a brown seaweed rich in vitamins and minerals, including dietary iodine. It has been used in traditional medicine systems for over 2,000 years — the Japanese and Chinese cultures used Kelp to address glandular concerns as long ago as 300 BC, while Pacific Northwest Indigenous peoples incorporated it into medicinal steam baths. Kelp contains bioactive polysaccharides including alginic acid, laminarin, and fucoidan. It is included in this formula as part of the supportive herbal base.
Licorice root
Licorice root (Glycyrrhiza glabra) has been used worldwide as a traditional medicine for over 4,000 years, with records in the Assyrian Herbal (2000 BC) and the Ebers Papyrus (1600 BC). It appears in approximately 60% of traditional Chinese medicine prescriptions. Historically, it has been valued for supporting respiratory comfort and digestive wellness. In this formula, Licorice root serves as part of the herbal base that complements the mineral components.
Peppermint leaves
Peppermint (Mentha × piperita) has been used as a remedy for indigestion since ancient Egyptian times, with dried leaves found in pyramids dating to 1000 BC. The ancient Greeks and Romans valued it as a stomach soother. Peppermint's primary constituent, menthol, blocks Calcium channels in smooth muscle, producing antispasmodic effects. The German Commission E approved Peppermint leaf for spastic complaints of the gastrointestinal tract. It is included here as part of the supportive herbal base.
White willow bark
White willow bark (Salix alba) has a history spanning over 3,500 years — Sumerians and Egyptians used it as a pain reliever, and Hippocrates reportedly prescribed it for fever and the pain of childbirth. The bark contains salicin, a natural compound that is metabolized to salicylic acid in the body. Willow bark has been traditionally used in European, Native American, and Chinese herbal traditions for muscle soreness, general aches, and inflammation. It is included in this formula as part of the herbal base.
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Who Benefits

Who Should Consider the Best Magnesium Glycinate

This formula may be a good fit for adults looking to support their nervous system, maintain healthy bone density, and promote comfortable muscle function. Because Magnesium is necessary for the function of over 300 enzymes, it touches virtually every body system — from energy production to proper elimination.

Older adults may find Magnesium support especially relevant. As we age, Magnesium absorption and retention can decrease, and older people are more susceptible to Magnesium deficiency due to factors like decreased absorption from food and increased medication use. Men older than 70 and teenage girls are identified as most likely to have low intakes.

If you're not sure whether a Magnesium supplement is right for your individual needs, our naturopath is available for a free consultation. We're happy to help you understand how Magnesium fits into your overall wellness routine.

Directions

How to Take This Magnesium Formula

Take 1 tablet daily with a meal. Each bottle contains 180 tablets, providing a generous six-month supply from a single bottle.

Taking Magnesium with food supports absorption and is gentler on the stomach. Because Calcium and Magnesium are nutritional partners that work best when taken together, this formula conveniently combines both minerals in a single tablet.

Sobre el autor

Escrito por Greg Howlett

GH

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

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Preguntas frecuentes

Why is this considered one of the best Magnesium glycinate options?

This Nature's Sunshine formula delivers 250 mg of Magnesium from both Magnesium oxide and Magnesium amino acid chelate, paired with complementary Calcium, Phosphorus, and a supportive herbal base. Magnesium amino acid chelate is absorbed via the dipeptide transporter pathway, and the formula is designed to support nervous system health, bone density, and muscle function. Magnesium glycinate is often recommended for individuals with sensitive digestive systems, as it tends to cause fewer gastrointestinal side effects.

What does Magnesium do in the body?

Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It is required for energy production (ATP synthesis), is involved in bone formation, and modulates neuronal excitability through NMDA receptor blockade. It also supports proper elimination and helps metabolize various nutrients such as vitamin C, Phosphorus, potassium, and sodium.

Why are Calcium and Magnesium included together?

Calcium and Magnesium are nutritional partners that work best when taken together. Calcium is the primary mineral component of bone and is essential for muscle contraction and nerve transmission. Magnesium is involved in bone formation and influences the concentrations of parathyroid hormone and active vitamin D — both major regulators of Calcium metabolism and bone homeostasis. This formula includes 40 mg of Calcium alongside 250 mg of Magnesium.

How many servings are in a bottle?

Each bottle contains 180 tablets. The serving size is 1 tablet daily, so one bottle provides a full six-month supply.

Can Magnesium help with muscle cramps?

Magnesium is the most studied mineral supplement for skeletal muscle cramps. Magnesium deficiency impairs muscle relaxation — muscles may contract normally but struggle to fully release when levels are low. While Cochrane reviews found it unlikely to provide meaningful cramp prevention in older adults with idiopathic cramps, evidence for pregnancy-associated leg cramps remains conflicting. Adequate Magnesium intake supports overall healthy muscle function.

What herbs are included in the base and why?

The formula includes a base of Licorice root, Kelp plant, Peppermint leaves, and White willow bark. Licorice root has over 4,000 years of traditional use and appears in approximately 60% of traditional Chinese medicine prescriptions. Kelp provides naturally occurring minerals including iodine and has been used in traditional medicine for over 2,000 years. Peppermint leaves have been traditionally valued since ancient Egyptian times for digestive comfort. White willow bark has been used traditionally across European, Native American, and Chinese traditions for muscle soreness and general aches.

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Best Magnesium Glycinate | Nervous System & Bone Support